July 2025 updates

papers/2025_simonich.md

@@ -1,7 +1,7 @@
 ---
 layout: paper
 title: "RSV F evolution escapes some monoclonal antibodies but does not strongly erode neutralization by human polyclonal sera"
-date: "2025-03-12"
+date: "2025-07-03"
 authors: 
     - "Cassandra AL Simonich"
     - "Teagan A McMahon"
@@ -13,9 +13,9 @@ authors:
     - "Neil P King"
     - "Alexander L Greninger"
     - "Jesse D Bloom"
-journal: "bioRxiv"
-doi: "10.1101/2025.03.11.642476"
-link: "https://doi.org/10.1101/2025.03.11.642476"
+journal: "Journal of Virology"
+doi: "10.1128/jvi.00531-25"
+link: "https://journals.asm.org/doi/10.1128/jvi.00531-25"
 image: "/assets/papers/2025_simonich.jpg"
 keywords:
     - "RSV"
@@ -24,4 +24,4 @@ selected: false
 ---
 
 ## Abstract
-Vaccines and monoclonal antibodies targeting the respiratory syncytial virus (RSV) fusion protein (F) have recently begun to be widely used to protect infants and high-risk adults. Some other viral proteins evolve to erode polyclonal antibody neutralization and escape individual monoclonal antibodies. However, little is known about how RSV F evolution affects antibodies. Here we develop an experimental system for measuring neutralization titers against RSV F using pseudotyped lentiviral particles. This system is easily adaptable to evaluate neutralization of relevant clinical strains. We apply this system to demonstrate that natural evolution of RSV F leads to escape from some monoclonal antibodies, but at most modestly affects neutralization by polyclonal serum antibodies. Overall, our work sheds light on RSV antigenic evolution and describes a tool to measure the ability of antibodies and sera to neutralize contemporary RSV strains.
+Vaccines and monoclonal antibodies targeting the respiratory syncytial virus (RSV) fusion protein (F) have recently begun to be widely used to protect infants and high-risk adults. Some other viral proteins evolve to erode polyclonal antibody neutralization and escape individual monoclonal antibodies. However, the impact of RSV F evolution on antibody neutralization is not yet thoroughly understood. Here, we develop an experimental system for measuring neutralization titers against RSV F using pseudotyped lentiviral particles. This system is easily adaptable to evaluate neutralization of relevant clinical strains. We apply this system to demonstrate that the natural evolution of RSV F leads to escape from some monoclonal antibodies, but at most modestly affects neutralization by polyclonal serum antibodies. Overall, our work sheds light on RSV antigenic evolution and describes a tool to measure the ability of antibodies and sera to neutralize contemporary RSV strains.

people/alumni.js

@@ -1,11 +1,19 @@
 export const alumni = [
+  {
+    name: "Will Hannon",
+    title: "Graduate Student",
+    program: "MCB",
+    start: "2021",
+    end: "2024",
+    currentPosition: "Scientist I at Allen Institute (SeaHub)",
+  },
   {
     name: "Frances Welsh",
     title: "Graduate Student",
     program: "MCB",
     start: "2020",
     end: "2024",
-    currentPosition: "Research Scientist at Amazon",
+    currentPosition: "Scientist at Xaira Therapeutics",
   },
   {
     name: "David Bacsik",
@@ -62,15 +70,15 @@ export const alumni = [
     start: "2015",
     end: "2019",
     currentPosition:
-      "Incoming <a href='https://katherinesxue.com/'>Assistant Professor</a> at the University of California, Irvine",
+      "<a href='https://katherinesxue.com/'>Assistant Professor</a> at the University of California, Irvine",
   },
   {
     name: "Juhye Lee",
     title: "Graduate Student",
     program: "MSTP and Genome Sciences",
     start: "2015",
     end: "2019",
-    currentPosition: "Resident at Massachusetts General Hospital",
+    currentPosition: "Hospitalist at Kaiser Permanente Orange Count",
   },
   {
     name: "Heather Machkovech",
@@ -79,7 +87,7 @@ export const alumni = [
     start: "2014",
     end: "2018",
     currentPosition:
-      "Internal Medicine resident at University of Wisconsin Hospital and Clinic",
+      "Infectious Disease Instructor at University of Wisconsin Hospital and Clinic",
   },
   {
     name: "Hugh Haddox",
@@ -180,7 +188,7 @@ export const alumni = [
     start: "2020",
     end: "2023",
     currentPosition:
-      "Incoming PhD student at UW Molecular and Cellular Biology",
+      "PhD student in UW Molecular and Cellular Biology",
   },
   {
     name: "Rosario Tarabi",
@@ -202,7 +210,7 @@ export const alumni = [
     title: "Staff Member",
     start: "2019",
     end: "2021",
-    currentPosition: "Teaching English in Tochigi Prefecture, Japan",
+    currentPosition: "Program Assistant at Fred Hutch",
   },
   {
     name: "Ian Gong",

people/bernadeta-dadonaite.md

@@ -2,7 +2,7 @@
 layout: person
 name: "Bernadeta Dadonaite"
 image: "/assets/people/bernadeta-dadonaite.jpg"
-title: "Staff Scientist"
+title: "Research Associate"
 category: "Staff"
 links:
   - link: "https://github.com/Bernadetadad"
@@ -13,4 +13,4 @@ links:
     icon: "email"
 ---
 
-Bernadeta is a staff scientist in the Bloom lab and works on deep mutational scanning of SARS-CoV-2 spike and H5 hemagglutinin.
+Bernadeta is a research associate working with the Bloom lab and works on deep mutational scanning of SARS-CoV-2 spike and H5 hemagglutinin.

people/jesse-bloom.md

@@ -2,8 +2,8 @@
 layout: person
 name: "Jesse Bloom"
 image: "/assets/people/jesse-bloom.jpg"
-title: "Principal Investigator"
-category: "Faculty"
+title: "Professor"
+category: "Staff"
 links:
   - link: "https://github.com/jbloom"
     icon: "github"