diff --git a/packages/react-native-gesture-handler/src/components/Pressable/Pressable.tsx b/packages/react-native-gesture-handler/src/components/Pressable/Pressable.tsx
index 26ab9e27e0..350fb5449f 100644
--- a/packages/react-native-gesture-handler/src/components/Pressable/Pressable.tsx
+++ b/packages/react-native-gesture-handler/src/components/Pressable/Pressable.tsx
@@ -36,6 +36,7 @@ import {
 } from '../utils';
 import { getStatesConfig, StateMachineEvent } from './stateDefinitions';
 import { PressableStateMachine } from './StateMachine';
+import { useIsScreenReaderEnabled } from '../../useIsScreenReaderEnabled';
 
 const DEFAULT_LONG_PRESS_DURATION = 500;
 const IS_TEST_ENV = isTestEnv();
@@ -202,11 +203,16 @@ const LegacyPressable = (props: LegacyPressableProps) => {
   );
 
   const stateMachine = useMemo(() => new PressableStateMachine(), []);
+  const isScreenReaderEnabled = useIsScreenReaderEnabled();
 
   useEffect(() => {
-    const configuration = getStatesConfig(handlePressIn, handlePressOut);
+    const configuration = getStatesConfig(
+      handlePressIn,
+      handlePressOut,
+      isScreenReaderEnabled
+    );
     stateMachine.setStates(configuration);
-  }, [handlePressIn, handlePressOut, stateMachine]);
+  }, [handlePressIn, handlePressOut, stateMachine, isScreenReaderEnabled]);
 
   const hoverInTimeout = useRef<number | null>(null);
   const hoverOutTimeout = useRef<number | null>(null);
@@ -259,7 +265,7 @@ const LegacyPressable = (props: LegacyPressableProps) => {
           );
         })
         .onTouchesUp(() => {
-          if (Platform.OS === 'android') {
+          if (Platform.OS === 'android' && !isScreenReaderEnabled) {
             // Prevents potential soft-locks
             stateMachine.reset();
             handleFinalize();
@@ -280,7 +286,7 @@ const LegacyPressable = (props: LegacyPressableProps) => {
             handleFinalize();
           }
         }),
-    [stateMachine, handleFinalize, handlePressOut]
+    [stateMachine, handleFinalize, handlePressOut, isScreenReaderEnabled]
   );
 
   // RNButton is placed inside ButtonGesture to enable Android's ripple and to capture non-propagating events
diff --git a/packages/react-native-gesture-handler/src/components/Pressable/stateDefinitions.ts b/packages/react-native-gesture-handler/src/components/Pressable/stateDefinitions.ts
index 55279211cd..af4fb93057 100644
--- a/packages/react-native-gesture-handler/src/components/Pressable/stateDefinitions.ts
+++ b/packages/react-native-gesture-handler/src/components/Pressable/stateDefinitions.ts
@@ -29,6 +29,25 @@ function getAndroidStatesConfig(
   ];
 }
 
+function getAndroidAccessibilityStatesConfig(
+  handlePressIn: (event: PressableEvent) => void,
+  handlePressOut: (event: PressableEvent) => void
+) {
+  return [
+    {
+      eventName: StateMachineEvent.LONG_PRESS_TOUCHES_DOWN,
+      callback: handlePressIn,
+    },
+    {
+      eventName: StateMachineEvent.NATIVE_BEGIN,
+    },
+    {
+      eventName: StateMachineEvent.FINALIZE,
+      callback: handlePressOut,
+    },
+  ];
+}
+
 function getIosStatesConfig(
   handlePressIn: (event: PressableEvent) => void,
   handlePressOut: (event: PressableEvent) => void
@@ -109,10 +128,13 @@ function getUniversalStatesConfig(
 
 export function getStatesConfig(
   handlePressIn: (event: PressableEvent) => void,
-  handlePressOut: (event: PressableEvent) => void
+  handlePressOut: (event: PressableEvent) => void,
+  screenReaderActive: boolean
 ): StateDefinition[] {
   if (Platform.OS === 'android') {
-    return getAndroidStatesConfig(handlePressIn, handlePressOut);
+    return screenReaderActive
+      ? getAndroidAccessibilityStatesConfig(handlePressIn, handlePressOut)
+      : getAndroidStatesConfig(handlePressIn, handlePressOut);
   } else if (Platform.OS === 'ios') {
     return getIosStatesConfig(handlePressIn, handlePressOut);
   } else if (Platform.OS === 'web') {
diff --git a/packages/react-native-gesture-handler/src/useIsScreenReaderEnabled.ts b/packages/react-native-gesture-handler/src/useIsScreenReaderEnabled.ts
new file mode 100644
index 0000000000..4d7dba945b
--- /dev/null
+++ b/packages/react-native-gesture-handler/src/useIsScreenReaderEnabled.ts
@@ -0,0 +1,31 @@
+import { useEffect, useState } from 'react';
+import { AccessibilityInfo } from 'react-native';
+
+export function useIsScreenReaderEnabled() {
+  const [isEnabled, setIsEnabled] = useState(false);
+
+  useEffect(() => {
+    const checkStatus = async () => {
+      try {
+        const res = await AccessibilityInfo.isScreenReaderEnabled();
+        setIsEnabled(res);
+      } catch (error) {
+        console.warn('Could not read accessibility info: defaulting to false');
+      }
+    };
+
+    checkStatus();
+
+    const listener = AccessibilityInfo.addEventListener(
+      'screenReaderChanged',
+      (enabled) => {
+        setIsEnabled(enabled);
+      }
+    );
+
+    return () => {
+      listener.remove();
+    };
+  }, []);
+  return isEnabled;
+}
diff --git a/packages/react-native-gesture-handler/src/v3/components/Pressable.tsx b/packages/react-native-gesture-handler/src/v3/components/Pressable.tsx
index 50d3ce15e5..245c250657 100644
--- a/packages/react-native-gesture-handler/src/v3/components/Pressable.tsx
+++ b/packages/react-native-gesture-handler/src/v3/components/Pressable.tsx
@@ -40,6 +40,7 @@ import { PureNativeButton } from './GestureButtons';
 
 import { PressabilityDebugView } from '../../handlers/PressabilityDebugView';
 import { INT32_MAX, isTestEnv } from '../../utils';
+import { useIsScreenReaderEnabled } from '../../useIsScreenReaderEnabled';
 
 const DEFAULT_LONG_PRESS_DURATION = 500;
 const IS_TEST_ENV = isTestEnv();
@@ -199,11 +200,16 @@ const Pressable = (props: PressableProps) => {
   );
 
   const stateMachine = useMemo(() => new PressableStateMachine(), []);
+  const isScreenReaderEnabled = useIsScreenReaderEnabled();
 
   useEffect(() => {
-    const configuration = getStatesConfig(handlePressIn, handlePressOut);
+    const configuration = getStatesConfig(
+      handlePressIn,
+      handlePressOut,
+      isScreenReaderEnabled
+    );
     stateMachine.setStates(configuration);
-  }, [handlePressIn, handlePressOut, stateMachine]);
+  }, [handlePressIn, handlePressOut, stateMachine, isScreenReaderEnabled]);
 
   const hoverInTimeout = useRef<number | null>(null);
   const hoverOutTimeout = useRef<number | null>(null);
@@ -257,7 +263,7 @@ const Pressable = (props: PressableProps) => {
       );
     },
     onTouchesUp: () => {
-      if (Platform.OS === 'android') {
+      if (Platform.OS === 'android' && !isScreenReaderEnabled) {
         // Prevents potential soft-locks
         stateMachine.reset();
         handleFinalize();