Calculations

[YuriGal]

Would it be possible to add filters by simple math, e.g. "Remove if reply_numbers/like_numbers < 2" ?

[Invertex]

You can already do this, the Remove node has options for that, including greater or less-than. Add multiple Remove nodes to do Reply and Likes.

[YuriGal]

This is what I currently do, I have a block that removes posts with replies < 100, and remove posts where likes > 50, and it sort of works, but is there a way to refine this?

[Invertex]

What about it isn't working? Those two blocks, one after the other, should do what you're asking...

Stash and Pop nodes can be used to store some result and hold onto it while you filter other stuff is another option to further control.

[YuriGal]

Because the conditions are independent, there could be a situation where, say post gains 200 replies and 51 likes. It should remain in the feed because the ratio is only ~ 4 (and the threshold is < 2), but it will be removed because number of likes is treated as an independent remove block.
I should probably play with stash/pop to see if I can use several conditions pairs to more granular filtering, thanks for the suggetion!