diff --git a/.github/dependabot.yml b/.github/dependabot.yml
index 59f10472d..164cd1cf0 100644
--- a/.github/dependabot.yml
+++ b/.github/dependabot.yml
@@ -17,3 +17,9 @@ updates:
     interval: weekly
   cooldown:
     default-days: 7
+- package-ecosystem: docker
+  directory: "/"
+  schedule:
+    interval: weekly
+  cooldown:
+    default-days: 7
diff --git a/Dockerfile b/Dockerfile
index 925a7d1e5..7cd2998b0 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -1,3 +1,5 @@
+FROM ghcr.io/astral-sh/uv:0.11.8@sha256:3b7b60a81d3c57ef471703e5c83fd4aaa33abcd403596fb22ab07db85ae91347 AS uv
+
 FROM python:3.12.6-bookworm
 ENV PYTHONUNBUFFERED=1
 ENV PYTHONDONTWRITEBYTECODE=1
@@ -32,16 +34,19 @@ RUN case $(uname -m) in \
 RUN mkdir /code
 WORKDIR /code
 
-RUN pip --no-cache-dir --disable-pip-version-check install --upgrade pip setuptools wheel
+COPY --from=uv /uv /uvx /usr/local/bin/
 
-COPY pyproject.toml /code/
+COPY pyproject.toml uv.lock /code/
 
-RUN --mount=type=cache,target=/root/.cache/pip \
+RUN --mount=type=cache,target=/root/.cache \
     set -x \
-    && pip --disable-pip-version-check \
-        install --group dev \
-        .
+    && uv sync \
+         --frozen \
+         --no-editable \
+         --no-install-project
 
 COPY . /code/
 
-RUN pip --disable-pip-version-check install --no-deps -e '.'
+RUN uv sync \
+      --frozen \
+      --no-editable
diff --git a/Dockerfile.cabotage b/Dockerfile.cabotage
index 614654d25..d900f4bc7 100644
--- a/Dockerfile.cabotage
+++ b/Dockerfile.cabotage
@@ -1,3 +1,5 @@
+FROM ghcr.io/astral-sh/uv:0.11.8@sha256:3b7b60a81d3c57ef471703e5c83fd4aaa33abcd403596fb22ab07db85ae91347 AS uv
+
 FROM python:3.12.6-bookworm
 COPY --from=ewdurbin/nginx-static:1.25.x /usr/bin/nginx /usr/bin/nginx
 ENV PYTHONUNBUFFERED=1
@@ -33,17 +35,25 @@ RUN case $(uname -m) in \
 RUN mkdir /code
 WORKDIR /code
 
-RUN pip --no-cache-dir --disable-pip-version-check install --upgrade pip setuptools wheel
+COPY --from=uv /uv /uvx /usr/local/bin/
 
-COPY pyproject.toml /code/
+COPY pyproject.toml uv.lock /code/
 
-RUN --mount=type=cache,target=/root/.cache/pip \
+RUN --mount=type=cache,target=/root/.cache \
     set -x \
-    && pip --disable-pip-version-check \
-        install \
-        '.[prod]'
+    && uv sync \
+         --frozen \
+         --no-editable \
+         --no-dev \
+         --extra prod \
+         --no-install-project
 
 COPY . /code/
 
-RUN pip --disable-pip-version-check install --no-deps '.'
-RUN DJANGO_SETTINGS_MODULE=pydotorg.settings.static python manage.py collectstatic --noinput
+RUN uv sync \
+      --frozen \
+      --no-editable \
+      --no-dev \
+      --extra prod
+
+RUN DJANGO_SETTINGS_MODULE=pydotorg.settings.static uv run python manage.py collectstatic --noinput
diff --git a/Makefile b/Makefile
index 77c976d48..42af8f689 100644
--- a/Makefile
+++ b/Makefile
@@ -16,8 +16,8 @@ help: ## Display this help text
 	mkdir -p .state && touch .state/db-migrated
 
 .state/db-initialized: .state/docker-build-web .state/db-migrated
-	docker compose run --rm web ./manage.py createcachetable
-	docker compose run --rm web ./manage.py loaddata fixtures/*.json
+	docker compose run --rm web uv run ./manage.py createcachetable
+	docker compose run --rm web uv run ./manage.py loaddata fixtures/*.json
 	mkdir -p .state && touch .state/db-initialized
 
 # =============================================================================
@@ -30,16 +30,16 @@ serve: .state/db-initialized ## Start the application
 	docker compose up --remove-orphans
 
 migrations: .state/db-initialized ## Generate migrations from models
-	docker compose run --rm web ./manage.py makemigrations
+	docker compose run --rm web uv run ./manage.py makemigrations
 
 migrate: .state/docker-build-web ## Run Django migrate
-	docker compose run --rm web ./manage.py migrate
+	docker compose run --rm web uv run ./manage.py migrate
 
 manage: .state/db-initialized ## Run arbitrary manage.py commands
-	docker compose run --rm web ./manage.py $(filter-out $@,$(MAKECMDGOALS))
+	docker compose run --rm web uv run ./manage.py $(filter-out $@,$(MAKECMDGOALS))
 
 shell: .state/db-initialized ## Open Django interactive shell
-	docker compose run --rm web ./manage.py shell
+	docker compose run --rm web uv run ./manage.py shell
 
 docker_shell: .state/db-initialized ## Open bash in web container
 	docker compose run --rm web /bin/bash
@@ -61,7 +61,7 @@ fmt: ## Run ruff formatter
 	@if command -v ruff >/dev/null 2>&1; then ruff format .; else docker compose run --rm web ruff format .; fi
 
 test: .state/db-initialized ## Run test suite
-	docker compose run --rm web ./manage.py test
+	docker compose run --rm web uv run python ./manage.py test
 
 ci: lint fmt test ## Run lint, fmt, then tests
 
diff --git a/docker-compose.yml b/docker-compose.yml
index 1f5ea36b4..38c3cebb5 100644
--- a/docker-compose.yml
+++ b/docker-compose.yml
@@ -23,7 +23,7 @@ services:
   web:
     build: .
     image: pythondotorg:docker-compose
-    command: python manage.py runserver 0.0.0.0:8000
+    command: uv run python manage.py runserver 0.0.0.0:8000
     volumes:
       - .:/code
     ports:
@@ -39,7 +39,7 @@ services:
 
   worker:
     image: pythondotorg:docker-compose
-    command: celery -A pydotorg worker -B -l INFO --scheduler django_celery_beat.schedulers:DatabaseScheduler
+    command: uv run celery -A pydotorg worker -B -l INFO --scheduler django_celery_beat.schedulers:DatabaseScheduler
     volumes:
       - .:/code
     environment: