diff --git a/Lib/asyncio/__main__.py b/Lib/asyncio/__main__.py
index 7f0565d0b8ddc7..708fdd595971e8 100644
--- a/Lib/asyncio/__main__.py
+++ b/Lib/asyncio/__main__.py
@@ -99,7 +99,7 @@ def run(self):
 
                 console.write(banner)
 
-            if not sys.flags.isolated and (startup_path := os.getenv("PYTHONSTARTUP")):
+            if not sys.flags.ignore_environment and (startup_path := os.getenv("PYTHONSTARTUP")):
                 sys.audit("cpython.run_startup", startup_path)
                 try:
                     import tokenize
@@ -200,7 +200,7 @@ def interrupt(self) -> None:
 
     sys.audit("cpython.run_stdin")
 
-    if os.getenv('PYTHON_BASIC_REPL'):
+    if not sys.flags.ignore_environment and os.getenv('PYTHON_BASIC_REPL'):
         CAN_USE_PYREPL = False
     else:
         try:
diff --git a/Misc/NEWS.d/next/Library/2026-05-06-23-13-40.gh-issue-149319.PLM93t.rst b/Misc/NEWS.d/next/Library/2026-05-06-23-13-40.gh-issue-149319.PLM93t.rst
new file mode 100644
index 00000000000000..0f60a2fe96b4a9
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-05-06-23-13-40.gh-issue-149319.PLM93t.rst
@@ -0,0 +1 @@
+Made the asyncio REPL omit the execution of ``PYTHONSTARTUP`` and consideration of ``PYTHON_BASIC_REPL`` when ``python -E`` is used. Contributed by Jonathan Dung.