diff --git a/src/github/credentials.ts b/src/github/credentials.ts
index ce2f62b102..18469f845c 100644
--- a/src/github/credentials.ts
+++ b/src/github/credentials.ts
@@ -454,6 +454,54 @@ export class CredentialStore extends Disposable {
 		github.isEmu = getUser.then(result => result.data.plan?.name === 'emu_user');
 	}
 
+	/**
+	 * Check if the user is authenticated and might benefit from checking account preferences.
+	 * Note: Due to VS Code API limitations, we cannot directly check if multiple accounts are available.
+	 * This method returns true if the user is authenticated, as they may have multiple accounts
+	 * configured in VS Code that they can switch to via the "Manage Account Preferences" command.
+	 */
+	public async isAuthenticatedForAccountPreferences(authProviderId: AuthProvider): Promise<boolean> {
+		return this.isAuthenticated(authProviderId);
+	}
+
+	/**
+	 * Show a modal dialog suggesting the user might be using the wrong GitHub account.
+	 * Offers to open the "Manage Account Preferences" command.
+	 * @param repoName The repository name that couldn't be accessed
+	 * @param authProviderId The authentication provider ID
+	 * @returns true if the user chose to manage account preferences, false otherwise
+	 */
+	public async showWrongAccountModal(repoName: string, authProviderId: AuthProvider): Promise<boolean> {
+		let accountName: string;
+		try {
+			const currentUser = await this.getCurrentUser(authProviderId);
+			accountName = currentUser?.login ?? vscode.l10n.t('your current account');
+		} catch {
+			accountName = vscode.l10n.t('your current account');
+		}
+
+		const manageAccountPreferences = vscode.l10n.t('Manage Account Preferences');
+		const result = await vscode.window.showErrorMessage(
+			vscode.l10n.t(
+				'Unable to access repository "{0}" with the current GitHub account ({1}). You may have multiple GitHub accounts configured. Would you like to check your account preferences?',
+				repoName,
+				accountName
+			),
+			{ modal: true },
+			manageAccountPreferences
+		);
+
+		if (result === manageAccountPreferences) {
+			try {
+				await vscode.commands.executeCommand('_account.manageAccountPreferences', 'GitHub.vscode-pull-request-github');
+			} catch (e) {
+				Logger.error(`Failed to open manage account preferences: ${e}`, CredentialStore.ID);
+			}
+			return true;
+		}
+		return false;
+	}
+
 	private async getSession(authProviderId: AuthProvider, getAuthSessionOptions: vscode.AuthenticationGetSessionOptions, scopes: string[], requireScopes: boolean): Promise<{ session: vscode.AuthenticationSession | undefined, isNew: boolean, scopes: string[] }> {
 		const existingSession = (getAuthSessionOptions.forceNewSession || requireScopes) ? undefined : await this.findExistingScopes(authProviderId);
 		if (existingSession?.session) {
diff --git a/src/github/folderRepositoryManager.ts b/src/github/folderRepositoryManager.ts
index dac84ca592..0850bb3782 100644
--- a/src/github/folderRepositoryManager.ts
+++ b/src/github/folderRepositoryManager.ts
@@ -1360,10 +1360,17 @@ export class FolderRepositoryManager extends Disposable {
 		} catch (e) {
 			Logger.error(`Fetching pull request with query failed: ${e}`, this.id);
 			if (e.status === 404) {
-				// not found
-				vscode.window.showWarningMessage(
-					`Fetching pull requests for remote ${githubRepository.remote.remoteName} with query failed, please check if the repo ${githubRepository.remote.owner}/${githubRepository.remote.repositoryName} is valid.`,
-				);
+				// not found - this might be due to using the wrong account
+				const repoName = `${githubRepository.remote.owner}/${githubRepository.remote.repositoryName}`;
+				const isAuthenticated = await this._credentialStore.isAuthenticatedForAccountPreferences(githubRepository.remote.authProviderId);
+				if (isAuthenticated) {
+					// Show modal suggesting the user might be using the wrong account
+					await this._credentialStore.showWrongAccountModal(repoName, githubRepository.remote.authProviderId);
+				} else {
+					vscode.window.showWarningMessage(
+						vscode.l10n.t('Fetching pull requests for remote {0} with query failed, please check if the repo {1} is valid.', githubRepository.remote.remoteName, repoName),
+					);
+				}
 			} else {
 				throw e;
 			}
diff --git a/src/view/treeNodes/categoryNode.ts b/src/view/treeNodes/categoryNode.ts
index b7f0d2baa2..00d289f519 100644
--- a/src/view/treeNodes/categoryNode.ts
+++ b/src/view/treeNodes/categoryNode.ts
@@ -5,7 +5,7 @@
 
 import * as vscode from 'vscode';
 import { RemoteInfo } from '../../../common/types';
-import { AuthenticationError } from '../../common/authentication';
+import { AuthenticationError, AuthProvider } from '../../common/authentication';
 import { DEV_MODE, PR_SETTINGS_NAMESPACE } from '../../common/settingKeys';
 import { ITelemetry } from '../../common/telemetry';
 import { toQueryUri } from '../../common/uri';
@@ -299,15 +299,29 @@ export class CategoryTreeNode extends TreeNode implements vscode.TreeItem {
 			} catch (e) {
 				if (this.isCopilot && (e.response.status === 422) && e.message.includes('the users do not exist')) {
 					// Skip it, it's copilot and the repo doesn't have copilot
+				} else if (e.status === 404 || e.response?.status === 404) {
+					// 404 errors might indicate wrong account - this is handled in folderRepositoryManager
+					// but we catch it here to prevent duplicate error messages
+					needLogin = e instanceof AuthenticationError;
 				} else {
 					const error = formatError(e);
 					const actions: string[] = [];
 					if (error.includes('Bad credentials')) {
 						actions.push(vscode.l10n.t('Login again'));
+					} else if (e.status === 403 || e.response?.status === 403) {
+						// 403 forbidden - user might not have access with current account
+						// Check both GitHub.com and Enterprise providers since we might have repos from either
+						const isAuthenticatedGitHub = await this.folderRepoManager.credentialStore.isAuthenticatedForAccountPreferences(AuthProvider.github);
+						const isAuthenticatedEnterprise = await this.folderRepoManager.credentialStore.isAuthenticatedForAccountPreferences(AuthProvider.githubEnterprise);
+						if (isAuthenticatedGitHub || isAuthenticatedEnterprise) {
+							actions.push(vscode.l10n.t('Check Account Preferences'));
+						}
 					}
 					vscode.window.showErrorMessage(vscode.l10n.t('Fetching pull requests failed: {0}', formatError(e)), ...actions).then(action => {
-						if (action && action === actions[0]) {
+						if (action === vscode.l10n.t('Login again')) {
 							this.folderRepoManager.credentialStore.recreate(vscode.l10n.t('Your login session is no longer valid.'));
+						} else if (action === vscode.l10n.t('Check Account Preferences')) {
+							vscode.commands.executeCommand('_account.manageAccountPreferences', 'GitHub.vscode-pull-request-github');
 						}
 					});
 					needLogin = e instanceof AuthenticationError;