diff --git a/papers/2025_simonich.md b/papers/2025_simonich.md index 0b7b9e2c..36c6304f 100644 --- a/papers/2025_simonich.md +++ b/papers/2025_simonich.md @@ -1,7 +1,7 @@ --- layout: paper title: "RSV F evolution escapes some monoclonal antibodies but does not strongly erode neutralization by human polyclonal sera" -date: "2025-03-12" +date: "2025-07-03" authors: - "Cassandra AL Simonich" - "Teagan A McMahon" @@ -13,9 +13,9 @@ authors: - "Neil P King" - "Alexander L Greninger" - "Jesse D Bloom" -journal: "bioRxiv" -doi: "10.1101/2025.03.11.642476" -link: "https://doi.org/10.1101/2025.03.11.642476" +journal: "Journal of Virology" +doi: "10.1128/jvi.00531-25" +link: "https://journals.asm.org/doi/10.1128/jvi.00531-25" image: "/assets/papers/2025_simonich.jpg" keywords: - "RSV" @@ -24,4 +24,4 @@ selected: false --- ## Abstract -Vaccines and monoclonal antibodies targeting the respiratory syncytial virus (RSV) fusion protein (F) have recently begun to be widely used to protect infants and high-risk adults. Some other viral proteins evolve to erode polyclonal antibody neutralization and escape individual monoclonal antibodies. However, little is known about how RSV F evolution affects antibodies. Here we develop an experimental system for measuring neutralization titers against RSV F using pseudotyped lentiviral particles. This system is easily adaptable to evaluate neutralization of relevant clinical strains. We apply this system to demonstrate that natural evolution of RSV F leads to escape from some monoclonal antibodies, but at most modestly affects neutralization by polyclonal serum antibodies. Overall, our work sheds light on RSV antigenic evolution and describes a tool to measure the ability of antibodies and sera to neutralize contemporary RSV strains. +Vaccines and monoclonal antibodies targeting the respiratory syncytial virus (RSV) fusion protein (F) have recently begun to be widely used to protect infants and high-risk adults. Some other viral proteins evolve to erode polyclonal antibody neutralization and escape individual monoclonal antibodies. However, the impact of RSV F evolution on antibody neutralization is not yet thoroughly understood. Here, we develop an experimental system for measuring neutralization titers against RSV F using pseudotyped lentiviral particles. This system is easily adaptable to evaluate neutralization of relevant clinical strains. We apply this system to demonstrate that the natural evolution of RSV F leads to escape from some monoclonal antibodies, but at most modestly affects neutralization by polyclonal serum antibodies. Overall, our work sheds light on RSV antigenic evolution and describes a tool to measure the ability of antibodies and sera to neutralize contemporary RSV strains. diff --git a/people/alumni.js b/people/alumni.js index dccfb4cb..4a738703 100644 --- a/people/alumni.js +++ b/people/alumni.js @@ -1,11 +1,19 @@ export const alumni = [ + { + name: "Will Hannon", + title: "Graduate Student", + program: "MCB", + start: "2021", + end: "2024", + currentPosition: "Scientist I at Allen Institute (SeaHub)", + }, { name: "Frances Welsh", title: "Graduate Student", program: "MCB", start: "2020", end: "2024", - currentPosition: "Research Scientist at Amazon", + currentPosition: "Scientist at Xaira Therapeutics", }, { name: "David Bacsik", @@ -62,7 +70,7 @@ export const alumni = [ start: "2015", end: "2019", currentPosition: - "Incoming Assistant Professor at the University of California, Irvine", + "Assistant Professor at the University of California, Irvine", }, { name: "Juhye Lee", @@ -70,7 +78,7 @@ export const alumni = [ program: "MSTP and Genome Sciences", start: "2015", end: "2019", - currentPosition: "Resident at Massachusetts General Hospital", + currentPosition: "Hospitalist at Kaiser Permanente Orange Count", }, { name: "Heather Machkovech", @@ -79,7 +87,7 @@ export const alumni = [ start: "2014", end: "2018", currentPosition: - "Internal Medicine resident at University of Wisconsin Hospital and Clinic", + "Infectious Disease Instructor at University of Wisconsin Hospital and Clinic", }, { name: "Hugh Haddox", @@ -180,7 +188,7 @@ export const alumni = [ start: "2020", end: "2023", currentPosition: - "Incoming PhD student at UW Molecular and Cellular Biology", + "PhD student in UW Molecular and Cellular Biology", }, { name: "Rosario Tarabi", @@ -202,7 +210,7 @@ export const alumni = [ title: "Staff Member", start: "2019", end: "2021", - currentPosition: "Teaching English in Tochigi Prefecture, Japan", + currentPosition: "Program Assistant at Fred Hutch", }, { name: "Ian Gong", diff --git a/people/bernadeta-dadonaite.md b/people/bernadeta-dadonaite.md index 8d046afd..e5f94982 100644 --- a/people/bernadeta-dadonaite.md +++ b/people/bernadeta-dadonaite.md @@ -2,7 +2,7 @@ layout: person name: "Bernadeta Dadonaite" image: "/assets/people/bernadeta-dadonaite.jpg" -title: "Staff Scientist" +title: "Research Associate" category: "Staff" links: - link: "https://github.com/Bernadetadad" @@ -13,4 +13,4 @@ links: icon: "email" --- -Bernadeta is a staff scientist in the Bloom lab and works on deep mutational scanning of SARS-CoV-2 spike and H5 hemagglutinin. +Bernadeta is a research associate working with the Bloom lab and works on deep mutational scanning of SARS-CoV-2 spike and H5 hemagglutinin. diff --git a/people/jesse-bloom.md b/people/jesse-bloom.md index 7174510a..2eb04c8a 100644 --- a/people/jesse-bloom.md +++ b/people/jesse-bloom.md @@ -2,8 +2,8 @@ layout: person name: "Jesse Bloom" image: "/assets/people/jesse-bloom.jpg" -title: "Principal Investigator" -category: "Faculty" +title: "Professor" +category: "Staff" links: - link: "https://github.com/jbloom" icon: "github" diff --git a/people/will-hannon.md b/people/will-hannon.md deleted file mode 100644 index db24a9aa..00000000 --- a/people/will-hannon.md +++ /dev/null @@ -1,16 +0,0 @@ ---- -layout: person -name: "Will Hannon" -image: "/assets/people/will-hannon.jpg" -title: "Data Scientist" -category: "Staff" -links: - - link: "https://github.com/WillHannon-MCB" - icon: "github" - - link: "https://www.linkedin.com/in/williamhannon/" - icon: "linkedin" - - link: "whannon@fredhutch.org" - icon: "email" ---- - -As a Data Scientist in the Bloom Lab, I develop and implement computational approaches to study viral evolution and communicate with our data. I’m interested in improving access to the information-rich datasets we generate to aid in antigen engineering, therapeutic design, viral surveillance, and gaining a better understanding of viral evolution. diff --git a/public/assets/people/will-hannon.jpg b/public/assets/people/will-hannon.jpg deleted file mode 100644 index 2d49b7c4..00000000 Binary files a/public/assets/people/will-hannon.jpg and /dev/null differ