diff --git a/core/src/components/segment-view/segment-view.tsx b/core/src/components/segment-view/segment-view.tsx
index 4023d46971c..73dc8a04cc0 100644
--- a/core/src/components/segment-view/segment-view.tsx
+++ b/core/src/components/segment-view/segment-view.tsx
@@ -47,6 +47,13 @@ export class SegmentView implements ComponentInterface {
   handleScroll(ev: Event) {
     const { scrollLeft, scrollWidth, clientWidth } = ev.target as HTMLElement;
     const max = scrollWidth - clientWidth;
+    // When only one content item is present max is 0 — skip to avoid NaN/Infinity scrollRatio.
+    // Still reset the timeout so isManualScroll isn't cleared prematurely if setContent
+    // started the timer and a stray scroll event arrives on a non-overflowing element.
+    if (max <= 0) {
+      this.resetScrollEndTimeout();
+      return;
+    }
     const scrollRatio = (isRTL(this.el) ? -1 : 1) * (scrollLeft / max);
 
     this.ionSegmentViewScroll.emit({
diff --git a/core/src/components/segment-view/test/basic/segment-view.e2e.ts b/core/src/components/segment-view/test/basic/segment-view.e2e.ts
index f3f35626eaa..a7f3afe4493 100644
--- a/core/src/components/segment-view/test/basic/segment-view.e2e.ts
+++ b/core/src/components/segment-view/test/basic/segment-view.e2e.ts
@@ -128,6 +128,37 @@ configs({ modes: ['md'] }).forEach(({ title, config }) => {
       await expect(segmentButton).toHaveClass(/segment-button-checked/);
     });
 
+    test('should not emit ionSegmentViewScroll with NaN or Infinity scrollRatio when only one content item is present', async ({
+      page,
+    }) => {
+      await page.setContent(
+        `
+        <ion-segment value="only">
+          <ion-segment-button content-id="only" value="only">
+            <ion-label>Only</ion-label>
+          </ion-segment-button>
+        </ion-segment>
+        <ion-segment-view>
+          <ion-segment-content id="only">Only</ion-segment-content>
+        </ion-segment-view>
+      `,
+        config
+      );
+
+      const ionSegmentViewScroll = await page.spyOnEvent('ionSegmentViewScroll');
+
+      // Programmatically dispatch a scroll event on the segment-view host element
+      // to simulate what the browser fires when scrollLeft changes.
+      await page.locator('ion-segment-view').evaluate((el: HTMLElement) => {
+        el.dispatchEvent(new Event('scroll', { bubbles: true }));
+      });
+
+      await page.waitForChanges();
+
+      // The max === 0 guard should prevent ionSegmentViewScroll from firing entirely.
+      expect(ionSegmentViewScroll).not.toHaveReceivedEvent();
+    });
+
     test('should set correct segment button as checked and show correct content when programmatically setting the segment value', async ({
       page,
     }) => {
diff --git a/core/src/components/segment/segment.tsx b/core/src/components/segment/segment.tsx
index 256ec21edae..1d2674ddb69 100644
--- a/core/src/components/segment/segment.tsx
+++ b/core/src/components/segment/segment.tsx
@@ -388,6 +388,7 @@ export class Segment implements ComponentInterface {
 
     const dispatchedFrom = ev.target as HTMLElement;
     const segmentViewEl = this.segmentViewEl as EventTarget;
+    
     const segmentEl = this.el;
 
     // Only update the indicator if the event was dispatched from the correct segment view