diff --git a/cores/nRF5/Arduino.h b/cores/nRF5/Arduino.h
index 9406454..a5bd4f2 100644
--- a/cores/nRF5/Arduino.h
+++ b/cores/nRF5/Arduino.h
@@ -54,16 +54,11 @@ void loop( void ) ;
   #include "WMath.h"
   #include "HardwareSerial.h"
   #include "pulse.h"
-#endif
-#include "delay.h"
-#include "binary.h"
-#ifdef __cplusplus
   #include "Uart.h"
 #endif
 
-#ifdef USE_TINYUSB
-  #include "Adafruit_USBD_CDC.h"
-#endif
+#include "delay.h"
+#include "binary.h"
 
 // Include board variant
 #include "variant.h"
diff --git a/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_TinyUSB_API.cpp b/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_TinyUSB_API.cpp
index 62a22a7..d183de7 100644
--- a/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_TinyUSB_API.cpp
+++ b/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_TinyUSB_API.cpp
@@ -26,8 +26,9 @@
 
 #if CFG_TUD_ENABLED || CFG_TUH_ENABLED
 
-#include "Adafruit_USBD_Device.h"
 #include "Arduino.h"
+#include "Adafruit_USBD_Device.h"
+#include "Adafruit_USBD_CDC.h"
 
 extern "C" {
 
diff --git a/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_TinyUSB_nrf.cpp b/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_TinyUSB_nrf.cpp
index ed3792a..28be147 100644
--- a/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_TinyUSB_nrf.cpp
+++ b/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_TinyUSB_nrf.cpp
@@ -31,6 +31,7 @@
 
 #include "Arduino.h"
 #include "Adafruit_USBD_Device.h"
+#include "Adafruit_TinyUSB_API.h"
 
 //--------------------------------------------------------------------+
 // MACRO TYPEDEF CONSTANT ENUM DECLARATION
diff --git a/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_USBD_CDC.h b/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_USBD_CDC.h
index 9c0952f..8db3eeb 100644
--- a/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_USBD_CDC.h
+++ b/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_USBD_CDC.h
@@ -93,11 +93,9 @@ class Adafruit_USBD_CDC : public Stream, public Adafruit_USBD_Interface {
   bool isValid(void) { return _instance != INVALID_INSTANCE; }
 };
 
-extern Adafruit_USBD_CDC SerialTinyUSB;
-
 // Built-in support "Serial" is assigned to TinyUSB CDC
 // CH32 defines Serial as alias in WSerial.h
-#if defined(USE_TINYUSB) && !defined(ARDUINO_ARCH_CH32)
+#if defined(USE_TINYUSB) && !defined(ARDUINO_ARCH_CH32) && USB_CDC_DEFAULT_SERIAL
 #define SerialTinyUSB Serial
 #endif
 
diff --git a/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_USBD_Device.cpp b/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_USBD_Device.cpp
index b044e15..e5b5363 100644
--- a/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_USBD_Device.cpp
+++ b/cores/nRF5/TinyUSB/Adafruit_TinyUSB_ArduinoCore/Adafruit_USBD_Device.cpp
@@ -259,8 +259,6 @@ bool Adafruit_USBD_Device::begin(uint8_t rhport) {
   config->bNumInterfaces = _itf_count;
 #endif
 #else
-  SerialTinyUSB.begin(115200);
-
   // Init device hardware and call tusb_init()
   TinyUSB_Port_InitDevice(rhport);
 #endif
diff --git a/cores/nRF5/Uart.cpp b/cores/nRF5/Uart.cpp
index 8e55eb8..b8e817c 100644
--- a/cores/nRF5/Uart.cpp
+++ b/cores/nRF5/Uart.cpp
@@ -256,7 +256,7 @@ Uart::operator bool() {
   #define NRF_UART0_IRQn UART0_IRQn
 #endif
 
-#if !defined(USB_CDC_DEFAULT_SERIAL)
+#if !USB_CDC_DEFAULT_SERIAL
 #  if defined(PIN_SERIAL_CTS) && defined(PIN_SERIAL_RTS)
       Uart Serial( NRF_UART0, NRF_UART0_IRQn, PIN_SERIAL_RX, PIN_SERIAL_TX, PIN_SERIAL_CTS, PIN_SERIAL_RTS );
 #  else
diff --git a/cores/nRF5/Uart.h b/cores/nRF5/Uart.h
index 27537ed..1569be8 100644
--- a/cores/nRF5/Uart.h
+++ b/cores/nRF5/Uart.h
@@ -28,6 +28,14 @@
 
 #include "variant.h"
 
+#ifndef USB_CDC_DEFAULT_SERIAL
+  #define USB_CDC_DEFAULT_SERIAL (0)
+#endif
+
+#if defined(USE_TINYUSB) && USB_CDC_DEFAULT_SERIAL
+  #include "Adafruit_USBD_CDC.h"
+#endif
+
 class Uart : public HardwareSerial
 {
   public:
@@ -78,7 +86,7 @@ class Uart : public HardwareSerial
 //
 // SERIAL_PORT_HARDWARE_OPEN  Hardware serial ports which are open for use.  Their RX & TX
 //                            pins are NOT connected to anything by default.
-#if defined(USB_CDC_DEFAULT_SERIAL)
+#if USB_CDC_DEFAULT_SERIAL
   #define SERIAL_PORT_MONITOR         Serial
   #define SERIAL_PORT_USBVIRTUAL      Serial
 
diff --git a/cores/nRF5/libc/printf/putchar.cpp b/cores/nRF5/libc/printf/putchar.cpp
index ce18af6..9d9de4f 100644
--- a/cores/nRF5/libc/printf/putchar.cpp
+++ b/cores/nRF5/libc/printf/putchar.cpp
@@ -68,7 +68,7 @@ extern "C"
             Serial.write((const uint8_t *)pbuf->buffer, pbuf->index);
             pbuf->index = 0;
         }
-#ifdef USB_CDC_DEFAULT_SERIAL
+#if USB_CDC_DEFAULT_SERIAL
         Serial.flush();
 #endif
     }
@@ -85,7 +85,7 @@ extern "C"
                 Serial.write('\r');
             }
             Serial.write(c);
-#ifdef USB_CDC_DEFAULT_SERIAL
+#if USB_CDC_DEFAULT_SERIAL
             Serial.flush();
 #endif
             return;
diff --git a/cores/nRF5/utils/debug_utils.cpp b/cores/nRF5/utils/debug_utils.cpp
index 4bcc8a9..7652b5e 100644
--- a/cores/nRF5/utils/debug_utils.cpp
+++ b/cores/nRF5/utils/debug_utils.cpp
@@ -177,7 +177,7 @@ static size_t capture_backtrace(uint32_t* backtrace_buffer, size_t buffer_size,
  */
 static void store_fault_to_ram(exception_frame* ef, uint32_t exc_return_val)
 {
-#ifdef USB_CDC_DEFAULT_SERIAL
+#if USB_CDC_DEFAULT_SERIAL
     volatile fault_data_t* fault = FAULT_DATA_ADDR;
     fault->magic = FAULT_DATA_MAGIC;
     fault->pc = ef->pc;
@@ -240,7 +240,7 @@ static void store_fault_to_ram(exception_frame* ef, uint32_t exc_return_val)
 static void print_exception_data(exception_frame* ef)
 {
 // If USB is used for Serial we must avoid using it in HardFault handler
-#ifndef USB_CDC_DEFAULT_SERIAL
+#if !USB_CDC_DEFAULT_SERIAL
     if (Serial)
     {
         Serial.println("\n======== HARD FAULT DETECTED ========");
@@ -320,7 +320,7 @@ static void print_exception_data(exception_frame* ef)
  */
 void check_and_report_fault()
 {
-#ifdef USB_CDC_DEFAULT_SERIAL
+#if USB_CDC_DEFAULT_SERIAL
     volatile fault_data_t* fault = FAULT_DATA_ADDR;
 
     if (fault->magic == FAULT_DATA_MAGIC)
diff --git a/variants/Seeed_XIAO_nRF52840_Sense/variant.h b/variants/Seeed_XIAO_nRF52840_Sense/variant.h
index f78b593..4a4c62e 100644
--- a/variants/Seeed_XIAO_nRF52840_Sense/variant.h
+++ b/variants/Seeed_XIAO_nRF52840_Sense/variant.h
@@ -85,9 +85,18 @@ static const uint8_t A5  = PIN_A5;
 #define PIN_NFC2                (31)
 
 // Serial interfaces
-#define PIN_SERIAL1_RX          (7)
-#define PIN_SERIAL1_TX          (6)
-#define USB_CDC_DEFAULT_SERIAL  1
+#ifndef USB_CDC_DEFAULT_SERIAL
+  #define USB_CDC_DEFAULT_SERIAL (1)
+#endif
+
+#if USB_CDC_DEFAULT_SERIAL
+  #define PIN_SERIAL1_RX         (7)
+  #define PIN_SERIAL1_TX         (6)
+#else
+  #define PIN_SERIAL_RX          (7)
+  #define PIN_SERIAL_TX          (6)
+  #define Serial1                Serial
+#endif
 
 // SPI Interfaces
 #define SPI_INTERFACES_COUNT    (2)
diff --git a/variants/circuitplayground_nrf52840/variant.h b/variants/circuitplayground_nrf52840/variant.h
index 3fcae26..572ba70 100644
--- a/variants/circuitplayground_nrf52840/variant.h
+++ b/variants/circuitplayground_nrf52840/variant.h
@@ -92,9 +92,18 @@ static const uint8_t A9  = PIN_A9 ;
 /*
  * Serial interfaces
  */
-#define PIN_SERIAL1_RX       (0)
-#define PIN_SERIAL1_TX       (1)
-#define USB_CDC_DEFAULT_SERIAL 1
+#ifndef USB_CDC_DEFAULT_SERIAL
+  #define USB_CDC_DEFAULT_SERIAL (1)
+#endif
+
+#if USB_CDC_DEFAULT_SERIAL
+  #define PIN_SERIAL1_RX         (0)
+  #define PIN_SERIAL1_TX         (1)
+#else
+  #define PIN_SERIAL_RX          (0)
+  #define PIN_SERIAL_TX          (1)
+  #define Serial1                Serial
+#endif
 
 /*
  * SPI Interfaces
diff --git a/variants/clue_nrf52840/variant.h b/variants/clue_nrf52840/variant.h
index 21fcc69..9fe6ce1 100644
--- a/variants/clue_nrf52840/variant.h
+++ b/variants/clue_nrf52840/variant.h
@@ -89,9 +89,18 @@ static const uint8_t A7  = PIN_A7 ;
 /*
  * Serial interfaces
  */
-#define PIN_SERIAL1_RX       (0)
-#define PIN_SERIAL1_TX       (1)
-#define USB_CDC_DEFAULT_SERIAL 1
+#ifndef USB_CDC_DEFAULT_SERIAL
+  #define USB_CDC_DEFAULT_SERIAL (1)
+#endif
+
+#if USB_CDC_DEFAULT_SERIAL
+  #define PIN_SERIAL1_RX         (0)
+  #define PIN_SERIAL1_TX         (1)
+#else
+  #define PIN_SERIAL_RX          (0)
+  #define PIN_SERIAL_TX          (1)
+  #define Serial1                Serial
+#endif
 
 /*
  * SPI Interfaces
diff --git a/variants/feather_nrf52840_express/variant.h b/variants/feather_nrf52840_express/variant.h
index 1499b71..133774a 100644
--- a/variants/feather_nrf52840_express/variant.h
+++ b/variants/feather_nrf52840_express/variant.h
@@ -91,9 +91,18 @@ static const uint8_t AREF = PIN_AREF;
 /*
  * Serial interfaces
  */
-#define PIN_SERIAL1_RX       (1)
-#define PIN_SERIAL1_TX       (0)
-#define USB_CDC_DEFAULT_SERIAL 1
+#ifndef USB_CDC_DEFAULT_SERIAL
+  #define USB_CDC_DEFAULT_SERIAL (1)
+#endif
+
+#if USB_CDC_DEFAULT_SERIAL
+  #define PIN_SERIAL1_RX         (1)
+  #define PIN_SERIAL1_TX         (0)
+#else
+  #define PIN_SERIAL_RX          (1)
+  #define PIN_SERIAL_TX          (0)
+  #define Serial1                Serial
+#endif
 
 /*
  * SPI Interfaces
diff --git a/variants/feather_nrf52840_sense/variant.h b/variants/feather_nrf52840_sense/variant.h
index 5d21d7e..9dd3da6 100644
--- a/variants/feather_nrf52840_sense/variant.h
+++ b/variants/feather_nrf52840_sense/variant.h
@@ -96,9 +96,18 @@ static const uint8_t AREF = PIN_AREF;
 /*
  * Serial interfaces
  */
-#define PIN_SERIAL1_RX       (1)
-#define PIN_SERIAL1_TX       (0)
-#define USB_CDC_DEFAULT_SERIAL 1
+#ifndef USB_CDC_DEFAULT_SERIAL
+  #define USB_CDC_DEFAULT_SERIAL (1)
+#endif
+
+#if USB_CDC_DEFAULT_SERIAL
+  #define PIN_SERIAL1_RX         (1)
+  #define PIN_SERIAL1_TX         (0)
+#else
+  #define PIN_SERIAL_RX          (1)
+  #define PIN_SERIAL_TX          (0)
+  #define Serial1                Serial
+#endif
 
 /*
  * SPI Interfaces
diff --git a/variants/itsybitsy_nrf52840_express/variant.h b/variants/itsybitsy_nrf52840_express/variant.h
index 8285dea..67d41ba 100644
--- a/variants/itsybitsy_nrf52840_express/variant.h
+++ b/variants/itsybitsy_nrf52840_express/variant.h
@@ -86,9 +86,18 @@ static const uint8_t A6  = PIN_A6 ;
 /*
  * Serial interfaces
  */
-#define PIN_SERIAL1_RX       (0)
-#define PIN_SERIAL1_TX       (1)
-#define USB_CDC_DEFAULT_SERIAL 1
+#ifndef USB_CDC_DEFAULT_SERIAL
+  #define USB_CDC_DEFAULT_SERIAL (1)
+#endif
+
+#if USB_CDC_DEFAULT_SERIAL
+  #define PIN_SERIAL1_RX         (0)
+  #define PIN_SERIAL1_TX         (1)
+#else
+  #define PIN_SERIAL_RX          (0)
+  #define PIN_SERIAL_TX          (1)
+  #define Serial1                Serial
+#endif
 
 /*
  * SPI Interfaces
diff --git a/variants/nRF52840_Dongle/variant.h b/variants/nRF52840_Dongle/variant.h
index 63db758..95949c4 100644
--- a/variants/nRF52840_Dongle/variant.h
+++ b/variants/nRF52840_Dongle/variant.h
@@ -91,10 +91,18 @@ static const uint8_t AREF = PIN_AREF;
  */
 
 // Arduino Header D0, D1
-#define PIN_SERIAL1_RX      (33) // P1.01
-#define PIN_SERIAL1_TX      (34) // P1.02
-#define USB_CDC_DEFAULT_SERIAL 1
+#ifndef USB_CDC_DEFAULT_SERIAL
+  #define USB_CDC_DEFAULT_SERIAL (1)
+#endif
 
+#if USB_CDC_DEFAULT_SERIAL
+  #define PIN_SERIAL1_RX         (33)
+  #define PIN_SERIAL1_TX         (34)
+#else
+  #define PIN_SERIAL_RX          (33)
+  #define PIN_SERIAL_TX          (34)
+  #define Serial1                Serial
+#endif
 
 /*
  * SPI Interfaces