diff --git a/CHANGELOG.md b/CHANGELOG.md
index 3b1726e96c..3d31a09c69 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -33,6 +33,7 @@
 ### Fixes
 
 - Defer initial navigation span creation until navigation container is registered ([#5789](https://github.com/getsentry/sentry-react-native/pull/5789))
+- Exclude server-only AI/MCP modules from native bundles, reducing bundle size by ~150kb ([#5802](https://github.com/getsentry/sentry-react-native/pull/5802))
 
 ### Dependencies
 
diff --git a/packages/core/src/js/tools/metroconfig.ts b/packages/core/src/js/tools/metroconfig.ts
index 14dbef5d51..46bb0aa300 100644
--- a/packages/core/src/js/tools/metroconfig.ts
+++ b/packages/core/src/js/tools/metroconfig.ts
@@ -91,6 +91,7 @@ export function withSentryConfig(
   if (includeWebReplay === false) {
     newConfig = withSentryResolver(newConfig, includeWebReplay);
   }
+  newConfig = withSentryExcludeServerOnlyResolver(newConfig);
   if (enableSourceContextInDevelopment) {
     newConfig = withSentryMiddleware(newConfig);
   }
@@ -128,6 +129,7 @@ export function getSentryExpoConfig(
   if (options.includeWebReplay === false) {
     newConfig = withSentryResolver(newConfig, options.includeWebReplay);
   }
+  newConfig = withSentryExcludeServerOnlyResolver(newConfig);
 
   if (options.enableSourceContextInDevelopment ?? true) {
     newConfig = withSentryMiddleware(newConfig);
@@ -274,6 +276,69 @@ Please follow one of the following options:
   };
 }
 
+/**
+ * Matches relative import paths to server-only AI/MCP modules within `@sentry/core`.
+ *
+ * Metro passes the module name as-written in the source code, so for imports inside
+ * `@sentry/core`'s barrel file like `export { ... } from './integrations/mcp-server/index.js'`,
+ * the `moduleName` will be `./integrations/mcp-server/index.js`.
+ */
+const SERVER_ONLY_MODULE_RE =
+  /\/(mcp-server|tracing\/(vercel-ai|openai|anthropic-ai|google-genai|langchain|langgraph)|utils\/ai)(\/|$)/;
+
+function isFromSentryCore(originModulePath: string): boolean {
+  return originModulePath.includes('@sentry/core');
+}
+
+/**
+ * Excludes server-only AI/MCP modules from native (Android/iOS) bundles.
+ */
+export function withSentryExcludeServerOnlyResolver(config: MetroConfig): MetroConfig {
+  const originalResolver = config.resolver?.resolveRequest as CustomResolver | CustomResolverBeforeMetro068 | undefined;
+
+  const sentryServerOnlyResolverRequest: CustomResolver = (
+    context: CustomResolutionContext,
+    moduleName: string,
+    platform: string | null,
+    oldMetroModuleName?: string,
+  ) => {
+    if (
+      (platform === 'android' || platform === 'ios') &&
+      isFromSentryCore((context as { originModulePath?: string }).originModulePath ?? '') &&
+      SERVER_ONLY_MODULE_RE.test(oldMetroModuleName ?? moduleName)
+    ) {
+      return { type: 'empty' } as Resolution;
+    }
+    if (originalResolver) {
+      return oldMetroModuleName
+        ? originalResolver(context, moduleName, platform, oldMetroModuleName)
+        : originalResolver(context, moduleName, platform);
+    }
+
+    // Prior 0.68, context.resolveRequest is sentryServerOnlyResolverRequest itself, which would cause infinite recursion.
+    if (context.resolveRequest === sentryServerOnlyResolverRequest) {
+      // eslint-disable-next-line no-console
+      console.error(
+        `Error: [@sentry/react-native/metro] Can not resolve the defaultResolver on Metro older than 0.68.
+Please include your resolverRequest on your metroconfig or update your Metro version to 0.68 or higher.
+If you are still facing issues, report the issue at http://www.github.com/getsentry/sentry-react-native/issues`,
+      );
+      // Return required for test.
+      return process.exit(-1);
+    }
+
+    return context.resolveRequest(context, moduleName, platform);
+  };
+
+  return {
+    ...config,
+    resolver: {
+      ...config.resolver,
+      resolveRequest: sentryServerOnlyResolverRequest,
+    },
+  };
+}
+
 type MetroFrame = Parameters<Required<Required<MetroConfig>['symbolicator']>['customizeFrame']>[0];
 type MetroCustomizeFrame = { readonly collapse?: boolean };
 type MetroCustomizeFrameReturnValue =
diff --git a/packages/core/test/tools/metroconfig.test.ts b/packages/core/test/tools/metroconfig.test.ts
index 18177fb71e..685dcb0fcb 100644
--- a/packages/core/test/tools/metroconfig.test.ts
+++ b/packages/core/test/tools/metroconfig.test.ts
@@ -5,6 +5,7 @@ import type { SentryExpoConfigOptions } from '../../src/js/tools/metroconfig';
 import {
   getSentryExpoConfig,
   withSentryBabelTransformer,
+  withSentryExcludeServerOnlyResolver,
   withSentryFramesCollapsed,
   withSentryResolver,
 } from '../../src/js/tools/metroconfig';
@@ -362,6 +363,118 @@ describe('metroconfig', () => {
       }
     });
   });
+  describe('withSentryExcludeServerOnlyResolver', () => {
+    const SENTRY_CORE_ORIGIN = '/project/node_modules/@sentry/core/build/esm/index.js';
+
+    let originalResolverMock: any;
+
+    // @ts-expect-error Can't see type CustomResolutionContext
+    let contextMock: CustomResolutionContext;
+    let config: MetroConfig = {};
+
+    beforeEach(() => {
+      originalResolverMock = jest.fn();
+      contextMock = {
+        resolveRequest: jest.fn(),
+        originModulePath: SENTRY_CORE_ORIGIN,
+      };
+
+      config = {
+        resolver: {
+          resolveRequest: originalResolverMock,
+        },
+      };
+    });
+
+    describe.each([
+      ['./integrations/mcp-server/index.js'],
+      ['./tracing/openai/index.js'],
+      ['./tracing/anthropic-ai/index.js'],
+      ['./tracing/google-genai/index.js'],
+      ['./tracing/vercel-ai/index.js'],
+      ['./tracing/langchain/index.js'],
+      ['./tracing/langgraph/index.js'],
+      ['./utils/ai/providerSkip.js'],
+    ])('with server-only module %s from @sentry/core', serverOnlyModule => {
+      test('removes module when platform is android', () => {
+        const modifiedConfig = withSentryExcludeServerOnlyResolver(config);
+        const result = modifiedConfig.resolver?.resolveRequest?.(contextMock, serverOnlyModule, 'android');
+
+        expect(result).toEqual({ type: 'empty' });
+        expect(originalResolverMock).not.toHaveBeenCalled();
+      });
+
+      test('removes module when platform is ios', () => {
+        const modifiedConfig = withSentryExcludeServerOnlyResolver(config);
+        const result = modifiedConfig.resolver?.resolveRequest?.(contextMock, serverOnlyModule, 'ios');
+
+        expect(result).toEqual({ type: 'empty' });
+        expect(originalResolverMock).not.toHaveBeenCalled();
+      });
+
+      test('keeps module when platform is web', () => {
+        const modifiedConfig = withSentryExcludeServerOnlyResolver(config);
+        modifiedConfig.resolver?.resolveRequest?.(contextMock, serverOnlyModule, 'web');
+
+        expect(originalResolverMock).toHaveBeenCalledWith(contextMock, serverOnlyModule, 'web');
+      });
+
+      test('keeps module when platform is null', () => {
+        const modifiedConfig = withSentryExcludeServerOnlyResolver(config);
+        modifiedConfig.resolver?.resolveRequest?.(contextMock, serverOnlyModule, null);
+
+        expect(originalResolverMock).toHaveBeenCalledWith(contextMock, serverOnlyModule, null);
+      });
+    });
+
+    test('does not exclude modules when origin is not @sentry/core', () => {
+      const nonSentryContext = {
+        ...contextMock,
+        originModulePath: '/project/node_modules/some-other-package/index.js',
+      };
+      const modifiedConfig = withSentryExcludeServerOnlyResolver(config);
+      modifiedConfig.resolver?.resolveRequest?.(nonSentryContext, './tracing/openai/index.js', 'android');
+
+      expect(originalResolverMock).toHaveBeenCalledWith(nonSentryContext, './tracing/openai/index.js', 'android');
+    });
+
+    test('does not exclude modules when originModulePath is not available', () => {
+      const noOriginContext = {
+        resolveRequest: jest.fn(),
+      };
+      const modifiedConfig = withSentryExcludeServerOnlyResolver(config);
+      modifiedConfig.resolver?.resolveRequest?.(noOriginContext, './tracing/openai/index.js', 'android');
+
+      expect(originalResolverMock).toHaveBeenCalledWith(noOriginContext, './tracing/openai/index.js', 'android');
+    });
+
+    test('calls originalResolver for non-AI modules on native platforms', () => {
+      const modifiedConfig = withSentryExcludeServerOnlyResolver(config);
+      modifiedConfig.resolver?.resolveRequest?.(contextMock, './exports.js', 'android');
+
+      expect(originalResolverMock).toHaveBeenCalledWith(contextMock, './exports.js', 'android');
+    });
+
+    test('falls back to context.resolveRequest when no originalResolver', () => {
+      const modifiedConfig = withSentryExcludeServerOnlyResolver({ resolver: {} });
+      modifiedConfig.resolver?.resolveRequest?.(contextMock, './exports.js', 'android');
+
+      expect(contextMock.resolveRequest).toHaveBeenCalledWith(contextMock, './exports.js', 'android');
+    });
+
+    test('exits process on old Metro when context.resolveRequest is the resolver itself (infinite recursion guard)', () => {
+      // @ts-expect-error mock.
+      const mockExit = jest.spyOn(process, 'exit').mockImplementation(() => {});
+      const modifiedConfig = withSentryExcludeServerOnlyResolver({ resolver: {} });
+
+      const resolver = modifiedConfig.resolver?.resolveRequest;
+      // Simulate old Metro behavior where context.resolveRequest === the resolver itself
+      const oldMetroContext = { resolveRequest: resolver };
+      resolver?.(oldMetroContext, './exports.js', 'android');
+
+      expect(mockExit).toHaveBeenCalledWith(-1);
+    });
+  });
 });
 
 // function create mock metro frame