diff --git a/CHANGELOG.md b/CHANGELOG.md
index 184585e6a3..ac3d4f0e0f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -12,6 +12,10 @@
 
 - Fallback to Current Activity Holder when React Context Activity is not present ([#4779](https://github.com/getsentry/sentry-react-native/pull/4779))
 
+### Fixes
+
+- Initialize Sentry Android with ApplicationContext if available ([#4780](https://github.com/getsentry/sentry-react-native/pull/4780))
+
 ### Dependencies
 
 - Bump Cocoa SDK from v8.49.1 to v8.49.2 ([#4792](https://github.com/getsentry/sentry-react-native/pull/4792))
diff --git a/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/RNSentryModuleInitWithApplicationTest.kt b/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/RNSentryModuleInitWithApplicationTest.kt
new file mode 100644
index 0000000000..7585335309
--- /dev/null
+++ b/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/RNSentryModuleInitWithApplicationTest.kt
@@ -0,0 +1,29 @@
+package io.sentry.react
+
+import android.app.Application
+import org.junit.Assert.assertSame
+import org.junit.Test
+import org.junit.runner.RunWith
+import org.mockito.Mockito.mock
+import org.mockito.kotlin.whenever
+import org.robolectric.RobolectricTestRunner
+
+@RunWith(RobolectricTestRunner::class)
+class RNSentryModuleInitWithApplicationTest {
+    @Test
+    fun `when application context is null fallback to react context`() {
+        val mockedReactContext = Utils.makeReactContextMock()
+        whenever(mockedReactContext.applicationContext).thenReturn(null)
+
+        assertSame(RNSentryModuleImpl(mockedReactContext).applicationContext, mockedReactContext)
+    }
+
+    @Test
+    fun `use application context if available`() {
+        val mockedApplicationContext = mock(Application::class.java)
+        val mockedReactContext = Utils.makeReactContextMock()
+        whenever(mockedReactContext.applicationContext).thenReturn(mockedApplicationContext)
+
+        assertSame(RNSentryModuleImpl(mockedReactContext).applicationContext, mockedApplicationContext)
+    }
+}
diff --git a/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/Utils.kt b/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/Utils.kt
index 989c2c0994..840e940917 100644
--- a/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/Utils.kt
+++ b/packages/core/RNSentryAndroidTester/app/src/test/java/io/sentry/react/Utils.kt
@@ -10,7 +10,7 @@ import org.mockito.kotlin.whenever
 
 class Utils {
     companion object {
-        fun createRNSentryModuleWithMockedContext(): RNSentryModuleImpl {
+        fun makeReactContextMock(): ReactApplicationContext {
             val packageManager = mock(PackageManager::class.java)
             val packageInfo = mock(PackageInfo::class.java)
 
@@ -18,9 +18,13 @@ class Utils {
             whenever(reactContext.packageManager).thenReturn(packageManager)
             whenever(packageManager.getPackageInfo(anyString(), anyInt())).thenReturn(packageInfo)
 
+            return reactContext
+        }
+
+        fun createRNSentryModuleWithMockedContext(): RNSentryModuleImpl {
             RNSentryModuleImpl.lastStartTimestampMs = -1
 
-            return RNSentryModuleImpl(reactContext)
+            return RNSentryModuleImpl(makeReactContextMock())
         }
     }
 }
diff --git a/packages/core/android/src/main/java/io/sentry/react/RNSentryModuleImpl.java b/packages/core/android/src/main/java/io/sentry/react/RNSentryModuleImpl.java
index 8a6beaa024..8f6c814db6 100644
--- a/packages/core/android/src/main/java/io/sentry/react/RNSentryModuleImpl.java
+++ b/packages/core/android/src/main/java/io/sentry/react/RNSentryModuleImpl.java
@@ -90,6 +90,7 @@
 import java.util.concurrent.CountDownLatch;
 import org.jetbrains.annotations.NotNull;
 import org.jetbrains.annotations.Nullable;
+import org.jetbrains.annotations.TestOnly;
 
 public class RNSentryModuleImpl {
 
@@ -177,12 +178,22 @@ public void initNativeReactNavigationNewFrameTracking(Promise promise) {
 
   public void initNativeSdk(final ReadableMap rnOptions, Promise promise) {
     SentryAndroid.init(
-        this.getReactApplicationContext(),
-        options -> getSentryAndroidOptions(options, rnOptions, logger));
+        getApplicationContext(), options -> getSentryAndroidOptions(options, rnOptions, logger));
 
     promise.resolve(true);
   }
 
+  @TestOnly
+  protected Context getApplicationContext() {
+    final Context context = this.getReactApplicationContext().getApplicationContext();
+    if (context == null) {
+      logger.log(
+          SentryLevel.ERROR, "ApplicationContext is null, using ReactApplicationContext fallback.");
+      return this.getReactApplicationContext();
+    }
+    return context;
+  }
+
   protected void getSentryAndroidOptions(
       @NotNull SentryAndroidOptions options, @NotNull ReadableMap rnOptions, ILogger logger) {
     @Nullable SdkVersion sdkVersion = options.getSdkVersion();