diff --git a/packages/node/src/integrations/tracing/prisma.ts b/packages/node/src/integrations/tracing/prisma.ts
index 503e8c1908a4..b81adc9552a8 100644
--- a/packages/node/src/integrations/tracing/prisma.ts
+++ b/packages/node/src/integrations/tracing/prisma.ts
@@ -58,11 +58,15 @@ interface PrismaOptions {
    * @deprecated This is no longer used, v5 works out of the box.
    */
   prismaInstrumentation?: Instrumentation;
+  /**
+   * Configuration passed through to the {@link PrismaInstrumentation} constructor.
+   */
+  instrumentationConfig?: ConstructorParameters<typeof PrismaInstrumentation>[0];
 }
 
 class SentryPrismaInteropInstrumentation extends PrismaInstrumentation {
-  public constructor() {
-    super();
+  public constructor(options?: PrismaOptions) {
+    super(options?.instrumentationConfig);
   }
 
   public enable(): void {
@@ -165,8 +169,8 @@ function engineSpanKindToOTELSpanKind(engineSpanKind: V5EngineSpanKind): SpanKin
   }
 }
 
-export const instrumentPrisma = generateInstrumentOnce<PrismaOptions>(INTEGRATION_NAME, _options => {
-  return new SentryPrismaInteropInstrumentation();
+export const instrumentPrisma = generateInstrumentOnce<PrismaOptions>(INTEGRATION_NAME, options => {
+  return new SentryPrismaInteropInstrumentation(options);
 });
 
 /**
@@ -201,11 +205,11 @@ export const instrumentPrisma = generateInstrumentOnce<PrismaOptions>(INTEGRATIO
  *    }
  *    ```
  */
-export const prismaIntegration = defineIntegration((_options?: PrismaOptions) => {
+export const prismaIntegration = defineIntegration((options?: PrismaOptions) => {
   return {
     name: INTEGRATION_NAME,
     setupOnce() {
-      instrumentPrisma();
+      instrumentPrisma(options);
     },
     setup(client) {
       // If no tracing helper exists, we skip any work here
diff --git a/packages/node/test/integrations/tracing/prisma.test.ts b/packages/node/test/integrations/tracing/prisma.test.ts
new file mode 100644
index 000000000000..7fb734d7193d
--- /dev/null
+++ b/packages/node/test/integrations/tracing/prisma.test.ts
@@ -0,0 +1,38 @@
+import { PrismaInstrumentation } from '@prisma/instrumentation';
+import { INSTRUMENTED } from '@sentry/node-core';
+import { beforeEach, describe, expect, it, type MockInstance, vi } from 'vitest';
+import { instrumentPrisma } from '../../../src/integrations/tracing/prisma';
+
+vi.mock('@prisma/instrumentation');
+
+describe('Prisma', () => {
+  beforeEach(() => {
+    vi.clearAllMocks();
+    delete INSTRUMENTED.Prisma;
+
+    (PrismaInstrumentation as unknown as MockInstance).mockImplementation(() => {
+      return {
+        setTracerProvider: () => undefined,
+        setMeterProvider: () => undefined,
+        getConfig: () => ({}),
+        setConfig: () => ({}),
+        enable: () => undefined,
+      };
+    });
+  });
+
+  it('defaults are correct for instrumentPrisma', () => {
+    instrumentPrisma();
+
+    expect(PrismaInstrumentation).toHaveBeenCalledTimes(1);
+    expect(PrismaInstrumentation).toHaveBeenCalledWith(undefined);
+  });
+
+  it('passes instrumentationConfig option to PrismaInstrumentation', () => {
+    const config = { ignoreSpanTypes: [] };
+    instrumentPrisma({ instrumentationConfig: config });
+
+    expect(PrismaInstrumentation).toHaveBeenCalledTimes(1);
+    expect(PrismaInstrumentation).toHaveBeenCalledWith(config);
+  });
+});