diff --git a/sqlmodel/main.py b/sqlmodel/main.py
index 300031de8b..c26a397eb9 100644
--- a/sqlmodel/main.py
+++ b/sqlmodel/main.py
@@ -738,7 +738,24 @@ def get_sqlalchemy_type(field: Any) -> Any:
     raise ValueError(f"{type_} has no matching SQLAlchemy type")
 
 
+def _create_union(args: tuple[Any, ...]) -> Any:
+    if len(args) == 1:
+        return args[0]
+    return args[0] | _create_union(args[1:])
+
+
 def get_column_from_field(field: Any) -> Column:  # type: ignore
+    if isinstance(field.annotation, TypeVar):
+        generic: TypeVar = field.annotation
+        if generic.__bound__ is not None:
+            field.annotation = generic.__bound__
+        elif generic.__constraints__ != ():
+            constraints = generic.__constraints__
+            field.annotation = _create_union(constraints)
+        else:
+            raise TypeError(
+                f"Invalid type used for {field}. Please define a bound or constraints."
+            )
     field_info = field
     sa_column = _get_sqlmodel_field_value(field_info, "sa_column", Undefined)
     if isinstance(sa_column, Column):
diff --git a/tests/test_generics.py b/tests/test_generics.py
new file mode 100644
index 0000000000..9ea22dc322
--- /dev/null
+++ b/tests/test_generics.py
@@ -0,0 +1,122 @@
+from enum import Enum
+from typing import Generic, Literal, TypeVar
+
+import pytest
+from sqlalchemy import create_engine
+from sqlmodel import Field, Session, SQLModel, select
+from typing_extensions import assert_type
+
+
+def test_generic_type_with_bound(clear_sqlmodel) -> None:
+    TagT = TypeVar("TagT", bound=int)
+
+    class HeroFields(SQLModel, Generic[TagT]):
+        tag: TagT
+
+    class Hero(HeroFields[int], table=True):
+        id: int | None = Field(default=None, primary_key=True)
+
+    engine = create_engine("sqlite://")
+    SQLModel.metadata.create_all(engine)
+
+    with Session(engine) as session:
+        tag_number = 67
+        hero = Hero(tag=tag_number)
+        session.add(hero)
+
+        hero = session.exec(select(Hero).where(Hero.tag == tag_number)).first()
+        assert hero is not None
+        assert hero.tag == tag_number
+
+
+def test_generic_type_with_constraints(clear_sqlmodel) -> None:
+    TagT = TypeVar("TagT", int, None)
+
+    class HeroFields(SQLModel, Generic[TagT]):
+        tag: TagT
+
+    class Hero(HeroFields[int], table=True):
+        id: int | None = Field(default=None, primary_key=True)
+
+    engine = create_engine("sqlite://")
+    SQLModel.metadata.create_all(engine)
+
+    with Session(engine) as session:
+        tag_number = 67
+        hero = Hero(tag=tag_number)
+        session.add(hero)
+
+        hero = session.exec(select(Hero).where(Hero.tag == tag_number)).first()
+        assert hero is not None
+        assert hero.tag == tag_number
+
+
+def test_generic_type_with_multiple_type_constraints_raises_error(
+    clear_sqlmodel,
+) -> None:
+    with pytest.raises(ValueError):
+        TagT = TypeVar("TagT", int, str)
+
+        class HeroFields(SQLModel, Generic[TagT]):
+            tag: TagT
+
+        class Hero(HeroFields[int], table=True):
+            id: int | None = Field(default=None, primary_key=True)
+
+
+def test_discriminated_union_with_generics(clear_sqlmodel) -> None:
+    AmountRefundedT = TypeVar("AmountRefundedT", bound=int | None)
+    RejectionMessageT = TypeVar("RejectionMessageT", bound=str | None)
+
+    class RefundStatus(str, Enum):
+        ACCEPTED = "ACCEPTED"
+        REJECTED = "REJECTED"
+
+    DiscriminantT = TypeVar("DiscriminantT", bound=RefundStatus)
+
+    class RefundRequestFields(
+        SQLModel, Generic[AmountRefundedT, RejectionMessageT, DiscriminantT]
+    ):
+        item_name: str
+        amount_refunded: AmountRefundedT
+        rejection_message: RejectionMessageT
+        status: DiscriminantT
+
+    class RefundRequest(
+        RefundRequestFields[int | None, str | None, RefundStatus], table=True
+    ):
+        id: int | None = Field(default=None, primary_key=True)
+        status: RefundStatus
+
+    class AcceptedRequest(RefundRequestFields[int, None, RefundStatus.ACCEPTED]):
+        amount_refunded: int
+        rejection_message: None = None
+        status: Literal[RefundStatus.ACCEPTED] = RefundStatus.ACCEPTED
+
+    class RejectedRequest(RefundRequestFields[None, str, RefundStatus.REJECTED]):
+        rejection_message: str
+        amount_refunded: None = None
+        status: Literal[RefundStatus.REJECTED] = RefundStatus.REJECTED
+
+    engine = create_engine("sqlite://")
+    SQLModel.metadata.create_all(engine)
+
+    with Session(engine) as session:
+        c = RejectedRequest(
+            item_name="EmptyJuice",
+            rejection_message="This item cannot be refunded because it has been emptied",
+        )
+        session.add(RefundRequest.model_validate(c.model_dump()))
+
+        requests = session.exec(
+            select(RefundRequest).where(
+                RefundRequest.status == RefundStatus.REJECTED,
+            )
+        ).all()
+        rejected_requests = [
+            RejectedRequest.model_validate(request.model_dump())
+            for request in requests
+            if request.status == RefundStatus.REJECTED
+        ]
+        assert_type(rejected_requests, list[RejectedRequest])
+        assert len(rejected_requests) == 1