diff --git a/src/ghstack/cli.py b/src/ghstack/cli.py
index 82c8cbc..1a7f4f7 100644
--- a/src/ghstack/cli.py
+++ b/src/ghstack/cli.py
@@ -263,6 +263,18 @@ def status(pull_request: str) -> None:
     "With --no-stack, we support only non-range identifiers, and will submit each commit "
     "listed in the command line.",
 )
+@click.option(
+    "--reviewer",
+    default=None,
+    help="Comma-separated list of GitHub usernames to add as reviewers to new PRs "
+    "(overrides .ghstackrc setting)",
+)
+@click.option(
+    "--label",
+    default=None,
+    help="Comma-separated list of labels to add to new PRs "
+    "(overrides .ghstackrc setting)",
+)
 @click.option(
     "--direct/--no-direct",
     "direct_opt",
@@ -286,6 +298,8 @@ def submit(
     base: Optional[str],
     revs: Tuple[str, ...],
     stack: bool,
+    reviewer: Optional[str],
+    label: Optional[str],
 ) -> None:
     """
     Submit or update a PR stack
@@ -307,6 +321,8 @@ def submit(
             revs=revs,
             stack=stack,
             direct_opt=direct_opt,
+            reviewer=reviewer if reviewer is not None else config.reviewer,
+            label=label if label is not None else config.label,
         )
 
 
diff --git a/src/ghstack/config.py b/src/ghstack/config.py
index ff78fe9..735ca10 100644
--- a/src/ghstack/config.py
+++ b/src/ghstack/config.py
@@ -107,6 +107,10 @@ def get_gh_cli_credentials(
         ("github_url", str),
         # Name of the upstream remote
         ("remote_name", str),
+        # Default reviewers to add to new pull requests (comma-separated usernames)
+        ("reviewer", Optional[str]),
+        # Default labels to add to new pull requests (comma-separated labels)
+        ("label", Optional[str]),
     ],
 )
 
@@ -287,6 +291,16 @@ def read_config(
     else:
         remote_name = "origin"
 
+    if config.has_option("ghstack", "reviewer"):
+        reviewer = config.get("ghstack", "reviewer")
+    else:
+        reviewer = None
+
+    if config.has_option("ghstack", "label"):
+        label = config.get("ghstack", "label")
+    else:
+        label = None
+
     if write_back:
         with open(config_path, "w") as f:
             config.write(f)
@@ -302,6 +316,8 @@ def read_config(
         default_project_dir=default_project_dir,
         github_url=github_url,
         remote_name=remote_name,
+        reviewer=reviewer,
+        label=label,
     )
     logging.debug(f"conf = {conf}")
     return conf
diff --git a/src/ghstack/github_fake.py b/src/ghstack/github_fake.py
index d82e969..622b6af 100644
--- a/src/ghstack/github_fake.py
+++ b/src/ghstack/github_fake.py
@@ -1,5 +1,6 @@
 #!/usr/bin/env python3
 
+import dataclasses
 import os.path
 import re
 from dataclasses import dataclass
@@ -271,6 +272,8 @@ class PullRequest(Node):
     # state: PullRequestState
     title: str
     url: str
+    reviewers: List[str] = dataclasses.field(default_factory=list)
+    labels: List[str] = dataclasses.field(default_factory=list)
 
     def repository(self, info: GraphQLResolveInfo) -> Repository:
         return github_state(info).repositories[self._repository]
@@ -473,6 +476,24 @@ def rest(self, method: str, path: str, **kwargs: Any) -> Any:
                     GitHubNumber(int(m.group(3))),
                     cast(CreateIssueCommentInput, kwargs),
                 )
+            if m := re.match(
+                r"^repos/([^/]+)/([^/]+)/pulls/([^/]+)/requested_reviewers", path
+            ):
+                # Handle adding reviewers
+                state = self.state
+                repo = state.repository(m.group(1), m.group(2))
+                pr = state.pull_request(repo, GitHubNumber(int(m.group(3))))
+                reviewers = kwargs.get("reviewers", [])
+                pr.reviewers.extend(reviewers)
+                return {}
+            if m := re.match(r"^repos/([^/]+)/([^/]+)/issues/([^/]+)/labels", path):
+                # Handle adding labels
+                state = self.state
+                repo = state.repository(m.group(1), m.group(2))
+                pr = state.pull_request(repo, GitHubNumber(int(m.group(3))))
+                labels = kwargs.get("labels", [])
+                pr.labels.extend(labels)
+                return {}
         elif method == "patch":
             if m := re.match(r"^repos/([^/]+)/([^/]+)(?:/pulls/([^/]+))?$", path):
                 owner, name, number = m.groups()
diff --git a/src/ghstack/submit.py b/src/ghstack/submit.py
index f7910c5..b9568b9 100644
--- a/src/ghstack/submit.py
+++ b/src/ghstack/submit.py
@@ -343,6 +343,12 @@ class Submitter:
     # merged.  If None, infer whether or not the PR should be direct or not.
     direct_opt: Optional[bool] = None
 
+    # Default reviewers to add to new pull requests (comma-separated usernames)
+    reviewer: Optional[str] = None
+
+    # Default labels to add to new pull requests (comma-separated labels)
+    label: Optional[str] = None
+
     # ~~~~~~~~~~~~~~~~~~~~~~~~
     # Computed in post init
 
@@ -1434,6 +1440,32 @@ def _create_pull_request(
             )
             comment_id = rc["id"]
 
+        # Add reviewers if specified
+        if self.reviewer:
+            reviewers = [r.strip() for r in self.reviewer.split(",") if r.strip()]
+            if reviewers:
+                try:
+                    self.github.post(
+                        f"repos/{self.repo_owner}/{self.repo_name}/pulls/{number}/requested_reviewers",
+                        reviewers=reviewers,
+                    )
+                    logging.info(f"Added reviewers: {', '.join(reviewers)}")
+                except Exception as e:
+                    logging.warning(f"Failed to add reviewers: {e}")
+
+        # Add labels if specified
+        if self.label:
+            labels = [label.strip() for label in self.label.split(",") if label.strip()]
+            if labels:
+                try:
+                    self.github.post(
+                        f"repos/{self.repo_owner}/{self.repo_name}/issues/{number}/labels",
+                        labels=labels,
+                    )
+                    logging.info(f"Added labels: {', '.join(labels)}")
+                except Exception as e:
+                    logging.warning(f"Failed to add labels: {e}")
+
         logging.info("Opened PR #{}".format(number))
 
         pull_request_resolved = ghstack.diff.PullRequestResolved(
diff --git a/src/ghstack/test_prelude.py b/src/ghstack/test_prelude.py
index a46d5a9..567fadb 100644
--- a/src/ghstack/test_prelude.py
+++ b/src/ghstack/test_prelude.py
@@ -51,6 +51,8 @@
     "get_sh",
     "get_upstream_sh",
     "get_github",
+    "get_pr_reviewers",
+    "get_pr_labels",
     "tick",
     "captured_output",
 ]
@@ -194,6 +196,8 @@ def gh_submit(
     base: Optional[str] = None,
     revs: Sequence[str] = (),
     stack: bool = True,
+    reviewer: Optional[str] = None,
+    label: Optional[str] = None,
 ) -> List[ghstack.submit.DiffMeta]:
     self = CTX
     r = ghstack.submit.main(
@@ -214,6 +218,8 @@ def gh_submit(
         revs=revs,
         stack=stack,
         check_invariants=True,
+        reviewer=reviewer,
+        label=label,
     )
     self.check_global_github_invariants(self.direct)
     return r
@@ -386,6 +392,26 @@ def is_direct() -> bool:
     return CTX.direct
 
 
+def get_github() -> ghstack.github_fake.FakeGitHubEndpoint:
+    return CTX.github
+
+
+def get_pr_reviewers(pr_number: int) -> List[str]:
+    """Get the reviewers for a PR number."""
+    github = get_github()
+    repo = github.state.repository("pytorch", "pytorch")
+    pr = github.state.pull_request(repo, ghstack.github_fake.GitHubNumber(pr_number))
+    return pr.reviewers
+
+
+def get_pr_labels(pr_number: int) -> List[str]:
+    """Get the labels for a PR number."""
+    github = get_github()
+    repo = github.state.repository("pytorch", "pytorch")
+    pr = github.state.pull_request(repo, ghstack.github_fake.GitHubNumber(pr_number))
+    return pr.labels
+
+
 def assert_eq(a: Any, b: Any) -> None:
     assert a == b, f"{a} != {b}"
 
@@ -419,9 +445,5 @@ def get_upstream_sh() -> ghstack.shell.Shell:
     return CTX.upstream_sh
 
 
-def get_github() -> ghstack.github.GitHubEndpoint:
-    return CTX.github
-
-
 def tick() -> None:
     CTX.sh.test_tick()
diff --git a/test/submit/cli_reviewer_and_label.py.test b/test/submit/cli_reviewer_and_label.py.test
new file mode 100644
index 0000000..117ba2b
--- /dev/null
+++ b/test/submit/cli_reviewer_and_label.py.test
@@ -0,0 +1,84 @@
+from ghstack.test_prelude import *
+
+init_test()
+
+# Create first commit with one set of reviewers/labels
+commit("A")
+(A,) = gh_submit("Initial commit", reviewer="reviewer1", label="bug")
+
+# Verify first PR has correct reviewers and labels
+assert_eq(get_pr_reviewers(500), ["reviewer1"])
+assert_eq(get_pr_labels(500), ["bug"])
+
+# Create second commit with different reviewers/labels
+commit("B")
+(A2, B) = gh_submit(
+    "Add B", reviewer="reviewer2,reviewer3", label="enhancement,priority-high"
+)
+
+# Verify second PR has correct reviewers and labels
+assert_eq(get_pr_reviewers(501), ["reviewer2", "reviewer3"])
+assert_eq(get_pr_labels(501), ["enhancement", "priority-high"])
+
+if is_direct():
+    assert_github_state(
+        """\
+        [O] #500 Commit A (gh/ezyang/1/head -> master)
+
+            This is commit A
+
+            * 9cb2ede Initial commit
+
+        [O] #501 Commit B (gh/ezyang/2/head -> gh/ezyang/1/head)
+
+            This is commit B
+
+            * d012f5c Add B
+
+        Repository state:
+
+            * d012f5c (gh/ezyang/2/next, gh/ezyang/2/head)
+            |    Add B
+            * 9cb2ede (gh/ezyang/1/next, gh/ezyang/1/head)
+            |    Initial commit
+            * dc8bfe4 (HEAD -> master)
+                 Initial commit
+        """
+    )
+else:
+    assert_github_state(
+        """\
+        [O] #500 Commit A (gh/ezyang/1/head -> gh/ezyang/1/base)
+
+            Stack:
+            * #501
+            * __->__ #500
+
+            This is commit A
+
+            * 62602bd Initial commit
+
+        [O] #501 Commit B (gh/ezyang/2/head -> gh/ezyang/2/base)
+
+            Stack:
+            * __->__ #501
+            * #500
+
+            This is commit B
+
+            * afd9aaf Add B
+
+        Repository state:
+
+            * afd9aaf (gh/ezyang/2/head)
+            |    Add B
+            * 5d2de57 (gh/ezyang/2/base)
+            |    Add B (base update)
+            | * 62602bd (gh/ezyang/1/head)
+            | |    Initial commit
+            | * 5956f18 (gh/ezyang/1/base)
+            |/     Initial commit (base update)
+            * dc8bfe4 (HEAD -> master)
+                 Initial commit
+        """,
+    )
diff --git a/test/submit/reviewer_and_label.py.test b/test/submit/reviewer_and_label.py.test
new file mode 100644
index 0000000..57fe7f4
--- /dev/null
+++ b/test/submit/reviewer_and_label.py.test
@@ -0,0 +1,52 @@
+from ghstack.test_prelude import *
+
+init_test()
+
+commit("A")
+(A,) = gh_submit(
+    "Initial commit", reviewer="reviewer1,reviewer2", label="bug,enhancement"
+)
+
+# Verify reviewers and labels were added
+assert_eq(get_pr_reviewers(500), ["reviewer1", "reviewer2"])
+assert_eq(get_pr_labels(500), ["bug", "enhancement"])
+
+if is_direct():
+    assert_github_state(
+        """\
+        [O] #500 Commit A (gh/ezyang/1/head -> master)
+
+            This is commit A
+
+            * 9cb2ede Initial commit
+
+        Repository state:
+
+            * 9cb2ede (gh/ezyang/1/next, gh/ezyang/1/head)
+            |    Initial commit
+            * dc8bfe4 (HEAD -> master)
+                 Initial commit
+        """
+    )
+else:
+    assert_github_state(
+        """\
+        [O] #500 Commit A (gh/ezyang/1/head -> gh/ezyang/1/base)
+
+            Stack:
+            * __->__ #500
+
+            This is commit A
+
+            * 62602bd Initial commit
+
+        Repository state:
+
+            * 62602bd (gh/ezyang/1/head)
+            |    Initial commit
+            * 5956f18 (gh/ezyang/1/base)
+            |    Initial commit (base update)
+            * dc8bfe4 (HEAD -> master)
+                 Initial commit
+        """,
+    )