diff --git a/test/other/test_emit_tsd_multivalue.c b/test/other/test_emit_tsd_multivalue.c
new file mode 100644
index 0000000000000..b4729720e41ab
--- /dev/null
+++ b/test/other/test_emit_tsd_multivalue.c
@@ -0,0 +1,14 @@
+#include <emscripten.h>
+
+struct Pair { int a; int b; };
+
+// Returning a small struct by value with the experimental multi-value ABI
+// causes clang to emit a wasm function with two return values (i32, i32).
+// This mirrors the shape wasm-bindgen produces for e.g. `pub fn foo() -> String`
+// (a ptr+len pair) on the wasm32-unknown-emscripten target.
+EMSCRIPTEN_KEEPALIVE struct Pair make_pair(int a, int b) {
+  struct Pair p = {a, b};
+  return p;
+}
+
+int main() {}
diff --git a/test/test_other.py b/test/test_other.py
index f77aa3e902129..72f79f9175db7 100644
--- a/test/test_other.py
+++ b/test/test_other.py
@@ -3803,6 +3803,21 @@ def test_emit_tsd_wasm_only(self):
     expected = 'Wasm only output is not compatible with --emit-tsd'
     self.assert_fail([EMCC, test_file('other/test_emit_tsd.c'), '--emit-tsd', 'test_emit_tsd_wasm_only.d.ts', '-o', 'out.wasm'], expected)
 
+  def test_emit_tsd_multivalue(self):
+    # A wasm export that returns multiple values (e.g. wasm-bindgen's
+    # ptr+len pair for `pub fn foo() -> String`) used to crash --emit-tsd
+    # with `AssertionError: One return type only supported`.  It should
+    # now surface as a TypeScript tuple return type.
+    self.run_process([EMCC, test_file('other/test_emit_tsd_multivalue.c'),
+                      '-mmultivalue', '-Xclang', '-target-abi', '-Xclang', 'experimental-mv',
+                      '--emit-tsd', 'test_emit_tsd_multivalue.d.ts',
+                      '-sMODULARIZE', '-sEXPORT_ES6',
+                      '-sEXPORT_KEEPALIVE',
+                      '-o', 'test_emit_tsd_multivalue.mjs'] +
+                     self.get_cflags())
+    actual = read_file('test_emit_tsd_multivalue.d.ts')
+    self.assertContained('_make_pair(_0: number, _1: number): [number, number];', actual)
+
   @requires_dev_dependency('typescript')
   def test_emit_tsd_heap(self):
     self.run_process([EMCC, test_file('other/test_emit_tsd.c'),
diff --git a/tools/emscripten.py b/tools/emscripten.py
index c801a7465a6e0..bb63d76c08a1b 100644
--- a/tools/emscripten.py
+++ b/tools/emscripten.py
@@ -695,11 +695,15 @@ def create_tsd(metadata, embind_tsd):
     for index, type in enumerate(functype.params):
       arguments.append(f"_{index}: {type_to_ts_type(type)}")
     out += f'  {mangled}({", ".join(arguments)}): '
-    assert len(functype.returns) <= 1, 'One return type only supported'
-    if functype.returns:
+    if len(functype.returns) == 0:
+      ret_ts_type = 'void'
+    elif len(functype.returns) == 1:
       ret_ts_type = type_to_ts_type(functype.returns[0])
     else:
-      ret_ts_type = 'void'
+      # Multi-value returns are valid wasm (e.g. wasm-bindgen emits them
+      # for `pub fn foo() -> String` as a (ptr, len) pair). Surface them
+      # as a TS tuple type; downstream glue (or .d.ts mergers) can refine.
+      ret_ts_type = '[' + ', '.join(type_to_ts_type(t) for t in functype.returns) + ']'
     if settings.ASYNCIFY == 2 and any(fnmatch.fnmatch(name, pat) for pat in settings.ASYNCIFY_EXPORTS):
       ret_ts_type = f'Promise<{ret_ts_type}>'
     out += f'{ret_ts_type};\n'