diff --git a/Makefile.pre.in b/Makefile.pre.in
index 0db27b6c46fa68..10f299819cd40f 100644
--- a/Makefile.pre.in
+++ b/Makefile.pre.in
@@ -61,6 +61,7 @@ DSYMUTIL_PATH=  @DSYMUTIL_PATH@
 CARGO_HOME=@CARGO_HOME@
 CARGO_TARGET_DIR=@CARGO_TARGET_DIR@
 CARGO_PROFILE=@CARGO_PROFILE@
+CARGO_TARGET=@CARGO_TARGET@
 
 GNULD=		@GNULD@
 
@@ -3373,7 +3374,7 @@ Python/thread.o: @THREADHEADERS@ $(srcdir)/Python/condvar.h
 # Module dependencies and platform-specific files
 
 cpython-sys: Modules/cpython-sys/Cargo.toml Modules/cpython-sys/build.rs Modules/cpython-sys/wrapper.h Modules/cpython-sys/parser.h
-	CARGO_TARGET_DIR=$(abs_builddir)/target PYTHON_BUILD_DIR=$(abs_builddir) cargo build --lib --locked --package cpython-sys --profile $(CARGO_PROFILE) --manifest-path $(srcdir)/Cargo.toml
+	CARGO_TARGET_DIR=$(abs_builddir)/target PYTHON_BUILD_DIR=$(abs_builddir) \$(CARGO_HOME)/bin/cargo build --lib --locked --package cpython-sys --profile $(CARGO_PROFILE) $(if $(CARGO_TARGET),--target=$(CARGO_TARGET)) --manifest-path $(srcdir)/Cargo.toml
 
 # force rebuild when header file or module build flavor (static/shared) is changed
 MODULE_DEPS_STATIC=Modules/config.c
diff --git a/Modules/makesetup b/Modules/makesetup
index 0368f1d017ac87..586e26dd5891b0 100755
--- a/Modules/makesetup
+++ b/Modules/makesetup
@@ -287,7 +287,7 @@ sed -e 's/[ 	]*#.*//' -e '/^[ 	]*$/d' |
 			libs=
 			# depends on the headers through cpython-sys
 			rule="$objs: cpython-sys \$(srcdir)/Cargo.toml \$(srcdir)/Cargo.lock \$(srcdir)/$srcdir/$manifest $prefixed_srcs \$(PYTHON_HEADERS)"
-			rule="$rule; CARGO_TARGET_DIR=\$(abs_builddir)/target PYTHON_BUILD_DIR=\$(abs_builddir) cargo build --lib --locked --package ${mods} --profile \$(CARGO_PROFILE) --manifest-path \$(srcdir)/Cargo.toml"
+			rule="$rule; CARGO_TARGET_DIR=\$(abs_builddir)/target PYTHON_BUILD_DIR=\$(abs_builddir) \$(CARGO_HOME)/bin/cargo build --lib --locked --package ${mods} --profile \$(CARGO_PROFILE) \$(if \$(CARGO_TARGET),--target=\$(CARGO_TARGET)) --manifest-path \$(srcdir)/Cargo.toml"
 			echo "$rule" >>$rulesf
 			for mod in $mods
 			do
diff --git a/configure b/configure
index fb959ad79bf6cb..8af7ee0e042e81 100755
--- a/configure
+++ b/configure
@@ -887,6 +887,7 @@ TCLTK_LIBS
 TCLTK_CFLAGS
 LIBSQLITE3_LIBS
 LIBSQLITE3_CFLAGS
+CARGO_TARGET
 CARGO_PROFILE
 CARGO_TARGET_DIR
 CARGO_HOME
@@ -16104,6 +16105,15 @@ else
     CARGO_TARGET_DIR='debug'
     CARGO_PROFILE='dev'
   fi
+  # Set CARGO_TARGET for cross-compilation
+  case "$host" in
+    aarch64-apple-ios-simulator)
+      CARGO_TARGET="aarch64-apple-ios-sim"
+      ;;
+    *)
+      CARGO_TARGET="$host"
+      ;;
+  esac
 fi
 
 
@@ -16113,6 +16123,7 @@ fi
 
 
 
+
   if test "$ac_sys_system" = "Emscripten" -a -z "$LIBSQLITE3_CFLAGS" -a -z "$LIBSQLITE3_LIBS"
 then :
 
diff --git a/configure.ac b/configure.ac
index 83a4c006c4feca..a3cc99c8add8c3 100644
--- a/configure.ac
+++ b/configure.ac
@@ -4328,10 +4328,20 @@ else
     CARGO_TARGET_DIR='debug'
     CARGO_PROFILE='dev'
   fi
+  # Set CARGO_TARGET for cross-compilation
+  case "$host" in
+    aarch64-apple-ios-simulator)
+      CARGO_TARGET="aarch64-apple-ios-sim"
+      ;;
+    *)
+      CARGO_TARGET="$host"
+      ;;
+  esac
 fi
 AC_SUBST([CARGO_HOME])
 AC_SUBST([CARGO_TARGET_DIR])
 AC_SUBST([CARGO_PROFILE])
+AC_SUBST([CARGO_TARGET])
 
 
 dnl detect sqlite3 from Emscripten emport