diff --git a/test/integration/accessibility_spec.mjs b/test/integration/accessibility_spec.mjs
index fed6eac5ddbb7..41f84adb100da 100644
--- a/test/integration/accessibility_spec.mjs
+++ b/test/integration/accessibility_spec.mjs
@@ -460,4 +460,42 @@ describe("accessibility", () => {
       );
     });
   });
+
+  describe("No alt-text with MathML", () => {
+    let pages;
+
+    beforeEach(async () => {
+      pages = await loadAndWait("bug2004951.pdf", ".textLayer");
+    });
+
+    afterEach(async () => {
+      await closePages(pages);
+    });
+
+    it("must check that there's no alt-text on the MathML node", async () => {
+      await Promise.all(
+        pages.map(async ([browserName, page]) => {
+          const isSanitizerSupported = await page.evaluate(() => {
+            try {
+              // eslint-disable-next-line no-undef
+              return typeof Sanitizer !== "undefined";
+            } catch {
+              return false;
+            }
+          });
+          const ariaLabel = await page.$eval(
+            "span[aria-owns='p3R_mc2']",
+            el => el.getAttribute("aria-label") || ""
+          );
+          if (isSanitizerSupported) {
+            expect(ariaLabel).withContext(`In ${browserName}`).toEqual("");
+          } else {
+            expect(ariaLabel)
+              .withContext(`In ${browserName}`)
+              .toEqual("cube root of , x plus y end cube root ");
+          }
+        })
+      );
+    });
+  });
 });
diff --git a/test/pdfs/.gitignore b/test/pdfs/.gitignore
index 6080768c93f9e..8278a7a025751 100644
--- a/test/pdfs/.gitignore
+++ b/test/pdfs/.gitignore
@@ -768,3 +768,4 @@
 !issue20513.pdf
 !issue20516.pdf
 !issue20489.pdf
+!bug2004951.pdf
diff --git a/test/pdfs/bug2004951.pdf b/test/pdfs/bug2004951.pdf
new file mode 100755
index 0000000000000..83a9e4fffee7f
Binary files /dev/null and b/test/pdfs/bug2004951.pdf differ
diff --git a/web/struct_tree_layer_builder.js b/web/struct_tree_layer_builder.js
index f52b6acc0934a..a2d1524a79f8c 100644
--- a/web/struct_tree_layer_builder.js
+++ b/web/struct_tree_layer_builder.js
@@ -370,6 +370,10 @@ class StructTreeLayerBuilder {
               elem.ariaHidden = true;
             }
           }
+          // For now, we don't want to keep the alt text if there's valid
+          // MathML (see https://github.com/w3c/mathml-aam/issues/37).
+          // TODO: Revisit this decision in the future.
+          delete node.alt;
         }
         if (
           !node.mathML &&
@@ -377,6 +381,7 @@ class StructTreeLayerBuilder {
           node.children[0].role !== "math"
         ) {
           element = document.createElementNS(MathMLNamespace, "math");
+          delete node.alt;
         }
       }
     }