Running the test/host_test.py fails on a second run:
$ ./host_test.py
Traceback (most recent call last):
File "./host_test.py", line 34, in <module>
print 'if_ver_major = %d; if_ver_minor = %d' % device.if_ver()
TypeError: %d format: a number is required, not NoneType
Rebooting the Arduino makes ./host_test.py work again, once.