diff --git a/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/ClientH2StreamMultiplexerFactory.java b/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/ClientH2StreamMultiplexerFactory.java
index 574834a74c..c2b9afeea3 100644
--- a/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/ClientH2StreamMultiplexerFactory.java
+++ b/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/ClientH2StreamMultiplexerFactory.java
@@ -36,6 +36,7 @@
 import org.apache.hc.core5.http.protocol.HttpProcessor;
 import org.apache.hc.core5.http2.config.H2Config;
 import org.apache.hc.core5.http2.frame.DefaultFrameFactory;
+import org.apache.hc.core5.http2.frame.FrameFactory;
 import org.apache.hc.core5.reactor.ProtocolIOSession;
 import org.apache.hc.core5.util.Args;
 
@@ -53,25 +54,38 @@ public final class ClientH2StreamMultiplexerFactory {
     private final H2Config h2Config;
     private final CharCodingConfig charCodingConfig;
     private final H2StreamListener streamListener;
+    private final FrameFactory frameFactory;
 
     public ClientH2StreamMultiplexerFactory(
             final HttpProcessor httpProcessor,
             final HandlerFactory<AsyncPushConsumer> pushHandlerFactory,
             final H2Config h2Config,
             final CharCodingConfig charCodingConfig,
-            final H2StreamListener streamListener) {
+            final H2StreamListener streamListener,
+            final FrameFactory frameFactory) {
         this.httpProcessor = Args.notNull(httpProcessor, "HTTP processor");
         this.pushHandlerFactory = pushHandlerFactory;
         this.h2Config = h2Config != null ? h2Config : H2Config.DEFAULT;
         this.charCodingConfig = charCodingConfig != null ? charCodingConfig : CharCodingConfig.DEFAULT;
         this.streamListener = streamListener;
+        this.frameFactory = frameFactory != null ? frameFactory : DefaultFrameFactory.INSTANCE;
+    }
+
+    public ClientH2StreamMultiplexerFactory(
+            final HttpProcessor httpProcessor,
+            final HandlerFactory<AsyncPushConsumer> pushHandlerFactory,
+            final H2Config h2Config,
+            final CharCodingConfig charCodingConfig,
+            final H2StreamListener streamListener
+    ) {
+        this(httpProcessor, pushHandlerFactory, h2Config, charCodingConfig, streamListener, null);
     }
 
     public ClientH2StreamMultiplexerFactory(
             final HttpProcessor httpProcessor,
             final HandlerFactory<AsyncPushConsumer> pushHandlerFactory,
             final H2StreamListener streamListener) {
-        this(httpProcessor, pushHandlerFactory, null, null, streamListener);
+        this(httpProcessor, pushHandlerFactory, null, null, streamListener, null);
     }
 
     public ClientH2StreamMultiplexerFactory(
@@ -81,7 +95,7 @@ public ClientH2StreamMultiplexerFactory(
     }
 
     public ClientH2StreamMultiplexer create(final ProtocolIOSession ioSession) {
-        return new ClientH2StreamMultiplexer(ioSession, DefaultFrameFactory.INSTANCE, httpProcessor,
+        return new ClientH2StreamMultiplexer(ioSession, frameFactory, httpProcessor,
                 pushHandlerFactory, h2Config, charCodingConfig, streamListener);
     }
 
diff --git a/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/ServerH2StreamMultiplexerFactory.java b/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/ServerH2StreamMultiplexerFactory.java
index 38f0c0850a..49b3876845 100644
--- a/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/ServerH2StreamMultiplexerFactory.java
+++ b/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/ServerH2StreamMultiplexerFactory.java
@@ -36,6 +36,7 @@
 import org.apache.hc.core5.http.protocol.HttpProcessor;
 import org.apache.hc.core5.http2.config.H2Config;
 import org.apache.hc.core5.http2.frame.DefaultFrameFactory;
+import org.apache.hc.core5.http2.frame.FrameFactory;
 import org.apache.hc.core5.reactor.ProtocolIOSession;
 import org.apache.hc.core5.util.Args;
 
@@ -53,24 +54,36 @@ public final class ServerH2StreamMultiplexerFactory {
     private final H2Config h2Config;
     private final CharCodingConfig charCodingConfig;
     private final H2StreamListener streamListener;
+    private final FrameFactory frameFactory;
 
     public ServerH2StreamMultiplexerFactory(
             final HttpProcessor httpProcessor,
             final HandlerFactory<AsyncServerExchangeHandler> exchangeHandlerFactory,
             final H2Config h2Config,
             final CharCodingConfig charCodingConfig,
-            final H2StreamListener streamListener) {
+            final H2StreamListener streamListener,
+            final FrameFactory frameFactory) {
         this.httpProcessor = Args.notNull(httpProcessor, "HTTP processor");
         this.exchangeHandlerFactory = Args.notNull(exchangeHandlerFactory, "Exchange handler factory");
         this.h2Config = h2Config != null ? h2Config : H2Config.DEFAULT;
         this.charCodingConfig = charCodingConfig != null ? charCodingConfig : CharCodingConfig.DEFAULT;
         this.streamListener = streamListener;
+        this.frameFactory = frameFactory != null ? frameFactory : DefaultFrameFactory.INSTANCE;
+    }
+
+    public ServerH2StreamMultiplexerFactory(
+            final HttpProcessor httpProcessor,
+            final HandlerFactory<AsyncServerExchangeHandler> exchangeHandlerFactory,
+            final H2Config h2Config,
+            final CharCodingConfig charCodingConfig,
+            final H2StreamListener streamListener) {
+        this(httpProcessor, exchangeHandlerFactory, h2Config, charCodingConfig, streamListener, null);
     }
 
     public ServerH2StreamMultiplexer create(final ProtocolIOSession ioSession) {
         return new ServerH2StreamMultiplexer(
                 ioSession,
-                DefaultFrameFactory.INSTANCE,
+                frameFactory,
                 httpProcessor,
                 exchangeHandlerFactory,
                 charCodingConfig,
diff --git a/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2MultiplexingRequesterBootstrap.java b/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2MultiplexingRequesterBootstrap.java
index c991dea817..a19e7913fc 100644
--- a/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2MultiplexingRequesterBootstrap.java
+++ b/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2MultiplexingRequesterBootstrap.java
@@ -40,6 +40,7 @@
 import org.apache.hc.core5.http.protocol.HttpProcessor;
 import org.apache.hc.core5.http.protocol.UriPatternType;
 import org.apache.hc.core5.http2.config.H2Config;
+import org.apache.hc.core5.http2.frame.FrameFactory;
 import org.apache.hc.core5.http2.impl.H2Processors;
 import org.apache.hc.core5.http2.impl.nio.ClientH2PrefaceHandler;
 import org.apache.hc.core5.http2.impl.nio.ClientH2StreamMultiplexerFactory;
@@ -71,6 +72,7 @@ public class H2MultiplexingRequesterBootstrap {
     private Callback<Exception> exceptionCallback;
     private IOSessionListener sessionListener;
     private H2StreamListener streamListener;
+    private FrameFactory frameFactory;
 
     private IOReactorMetricsListener threadPoolListener;
 
@@ -188,6 +190,17 @@ public final H2MultiplexingRequesterBootstrap setStreamListener(final H2StreamLi
         return this;
     }
 
+    /**
+     * Sets {@link FrameFactory} instance.
+     *
+     * @since 5.4
+     * @return this instance.
+     */
+    public final H2MultiplexingRequesterBootstrap setStreamListener(final FrameFactory frameFactory) {
+        this.frameFactory = frameFactory;
+        return this;
+    }
+
     /**
      * Sets {@link UriPatternType} for handler registration.
      *
@@ -249,7 +262,8 @@ public H2MultiplexingRequester create() {
                 new DefaultAsyncPushConsumerFactory(requestRouter),
                 h2Config != null ? h2Config : H2Config.DEFAULT,
                 charCodingConfig != null ? charCodingConfig : CharCodingConfig.DEFAULT,
-                streamListener);
+                streamListener,
+                frameFactory);
         return new H2MultiplexingRequester(
                 ioReactorConfig,
                 (ioSession, attachment) ->
diff --git a/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2RequesterBootstrap.java b/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2RequesterBootstrap.java
index 8fb0a0c2ad..9d0f767d01 100644
--- a/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2RequesterBootstrap.java
+++ b/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2RequesterBootstrap.java
@@ -50,6 +50,7 @@
 import org.apache.hc.core5.http.protocol.UriPatternType;
 import org.apache.hc.core5.http2.HttpVersionPolicy;
 import org.apache.hc.core5.http2.config.H2Config;
+import org.apache.hc.core5.http2.frame.FrameFactory;
 import org.apache.hc.core5.http2.impl.H2Processors;
 import org.apache.hc.core5.http2.impl.nio.ClientH2StreamMultiplexerFactory;
 import org.apache.hc.core5.http2.impl.nio.ClientHttpProtocolNegotiationStarter;
@@ -101,6 +102,7 @@ public class H2RequesterBootstrap {
     private Http1StreamListener http1StreamListener;
     private ConnPoolListener<HttpHost> connPoolListener;
     private IOReactorMetricsListener threadPoolListener;
+    private FrameFactory frameFactory;
 
 
     private H2RequesterBootstrap() {
@@ -303,6 +305,17 @@ public final H2RequesterBootstrap setUriPatternType(final UriPatternType uriPatt
         return this;
     }
 
+    /**
+     * Sets {@link FrameFactory} instance.
+     *
+     * @since 5.4
+     * @return this instance.
+     */
+    public final H2RequesterBootstrap setFrameFactory(final FrameFactory frameFactory) {
+        this.frameFactory = frameFactory;
+        return this;
+    }
+
     /**
      * Registers the given {@link AsyncPushConsumer} {@link Supplier} as a default handler for URIs
      * matching the given pattern.
@@ -376,7 +389,8 @@ public H2AsyncRequester create() {
                 new DefaultAsyncPushConsumerFactory(requestRouter),
                 h2Config != null ? h2Config : H2Config.DEFAULT,
                 charCodingConfig != null ? charCodingConfig : CharCodingConfig.DEFAULT,
-                streamListener);
+                streamListener,
+                frameFactory);
 
         final TlsStrategy actualTlsStrategy = tlsStrategy != null ? tlsStrategy : new H2ClientTlsStrategy();
 
diff --git a/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2ServerBootstrap.java b/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2ServerBootstrap.java
index 73ccb12c3e..1d2aab3ce9 100644
--- a/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2ServerBootstrap.java
+++ b/httpcore5-h2/src/main/java/org/apache/hc/core5/http2/impl/nio/bootstrap/H2ServerBootstrap.java
@@ -62,6 +62,7 @@
 import org.apache.hc.core5.http.protocol.UriPatternType;
 import org.apache.hc.core5.http2.HttpVersionPolicy;
 import org.apache.hc.core5.http2.config.H2Config;
+import org.apache.hc.core5.http2.frame.FrameFactory;
 import org.apache.hc.core5.http2.impl.H2Processors;
 import org.apache.hc.core5.http2.impl.nio.H2StreamListener;
 import org.apache.hc.core5.http2.impl.nio.ServerH2StreamMultiplexerFactory;
@@ -104,6 +105,7 @@ public class H2ServerBootstrap {
     private H2StreamListener h2StreamListener;
     private Http1StreamListener http1StreamListener;
     private IOReactorMetricsListener threadPoolListener;
+    private FrameFactory frameFactory;
 
     private H2ServerBootstrap() {
         this.routeEntries = new ArrayList<>();
@@ -252,6 +254,17 @@ public final H2ServerBootstrap setStreamListener(final H2StreamListener h2Stream
         return this;
     }
 
+    /**
+     * Sets {@link FrameFactory} instance.
+     *
+     * @since 5.4
+     * @return this instance.
+     */
+    public final H2ServerBootstrap setFrameFactory(final FrameFactory frameFactory) {
+        this.frameFactory = frameFactory;
+        return this;
+    }
+
     /**
      * Sets {@link Http1StreamListener} instance.
      *
@@ -511,7 +524,8 @@ public HttpAsyncServer create() {
                 handlerFactory,
                 h2Config != null ? h2Config : H2Config.DEFAULT,
                 charCodingConfig != null ? charCodingConfig : CharCodingConfig.DEFAULT,
-                h2StreamListener);
+                h2StreamListener,
+                frameFactory);
 
         final TlsStrategy actualTlsStrategy = tlsStrategy != null ? tlsStrategy : new H2ServerTlsStrategy();