diff --git a/sdks/python/pyproject.toml b/sdks/python/pyproject.toml
index 5adedb63a2ce..19a756659b5a 100644
--- a/sdks/python/pyproject.toml
+++ b/sdks/python/pyproject.toml
@@ -23,7 +23,7 @@ requires = [
     "wheel>=0.36.0",
     "grpcio-tools==1.62.1; python_version <= '3.12'",
     "grpcio-tools==1.71.0; python_version >= '3.13'",
-    "mypy-protobuf==3.5.0",
+    "mypy-protobuf==4.0.0",
     # Avoid https://github.com/pypa/virtualenv/issues/2006
     "distlib==0.3.9",
     # Numpy headers