diff --git a/packages/main/cypress/specs/ComboBox.cy.tsx b/packages/main/cypress/specs/ComboBox.cy.tsx
index cbea94de23ec..784e1edf0a21 100644
--- a/packages/main/cypress/specs/ComboBox.cy.tsx
+++ b/packages/main/cypress/specs/ComboBox.cy.tsx
@@ -2974,6 +2974,60 @@ describe("ComboBox Composition", () => {
 	});
 });
 
+describe("Loading State", () => {
+	it("should display busy indicator when loading is true", () => {
+		cy.mount(
+			<ComboBox loading open>
+				<ComboBoxItem text="Item 1" />
+				<ComboBoxItem text="Item 2" />
+			</ComboBox>
+		);
+
+		cy.get("[ui5-combobox]")
+			.shadow()
+			.find("ui5-responsive-popover")
+			.as("popover");
+
+		cy.get("@popover")
+			.find("ui5-busy-indicator")
+			.should("exist");
+
+		cy.get("@popover")
+			.find("ui5-list")
+			.should("not.exist");
+	});
+
+	it("should hide busy indicator and show items when loading becomes false", () => {
+		cy.mount(
+			<ComboBox loading open>
+				<ComboBoxItem text="Item 1" />
+				<ComboBoxItem text="Item 2" />
+			</ComboBox>
+		);
+
+		cy.get("[ui5-combobox]")
+			.as("combo")
+			.shadow()
+			.find("ui5-responsive-popover")
+			.as("popover");
+
+		cy.get("@popover")
+			.find("ui5-busy-indicator")
+			.should("exist");
+
+		cy.get("@combo")
+			.invoke("prop", "loading", false);
+
+		cy.get("@popover")
+			.find("ui5-busy-indicator")
+			.should("not.exist");
+
+		cy.get("@popover")
+			.find("ui5-list")
+			.should("exist");
+	});
+});
+
 describe("Validation inside a form", () => {
 	it("has correct validity for valueMissing", () => {
 		cy.mount(
diff --git a/packages/main/cypress/specs/MultiComboBox.cy.tsx b/packages/main/cypress/specs/MultiComboBox.cy.tsx
index f3ec04e0dda0..c64b42ceb8aa 100644
--- a/packages/main/cypress/specs/MultiComboBox.cy.tsx
+++ b/packages/main/cypress/specs/MultiComboBox.cy.tsx
@@ -4442,6 +4442,60 @@ describe("MultiComboBox Composition", () => {
 	});
 });
 
+describe("Loading State", () => {
+	it("should display busy indicator when loading is true", () => {
+		cy.mount(
+			<MultiComboBox loading open>
+				<MultiComboBoxItem text="Item 1" />
+				<MultiComboBoxItem text="Item 2" />
+			</MultiComboBox>
+		);
+
+		cy.get("[ui5-multi-combobox]")
+			.shadow()
+			.find("ui5-responsive-popover")
+			.as("popover");
+
+		cy.get("@popover")
+			.find("ui5-busy-indicator")
+			.should("exist");
+
+		cy.get("@popover")
+			.find("ui5-list")
+			.should("not.exist");
+	});
+
+	it("should hide busy indicator and show items when loading becomes false", () => {
+		cy.mount(
+			<MultiComboBox loading open>
+				<MultiComboBoxItem text="Item 1" />
+				<MultiComboBoxItem text="Item 2" />
+			</MultiComboBox>
+		);
+
+		cy.get("[ui5-multi-combobox]")
+			.as("mcb")
+			.shadow()
+			.find("ui5-responsive-popover")
+			.as("popover");
+
+		cy.get("@popover")
+			.find("ui5-busy-indicator")
+			.should("exist");
+
+		cy.get("@mcb")
+			.invoke("prop", "loading", false);
+
+		cy.get("@popover")
+			.find("ui5-busy-indicator")
+			.should("not.exist");
+
+		cy.get("@popover")
+			.find("ui5-list")
+			.should("exist");
+	});
+});
+
 describe("Validation inside a form", () => {
 	it("has correct validity for valueMissing", () => {
 		cy.mount(
diff --git a/packages/main/src/ComboBoxPopoverTemplate.tsx b/packages/main/src/ComboBoxPopoverTemplate.tsx
index 77a483304361..378e70ca2f95 100644
--- a/packages/main/src/ComboBoxPopoverTemplate.tsx
+++ b/packages/main/src/ComboBoxPopoverTemplate.tsx
@@ -31,9 +31,11 @@ export default function ComboBoxPopoverTemplate(this: ComboBox) {
 				onKeyDown={this._handlePopoverKeydown}
 				onFocusOut={this._handlePopoverFocusout}
 			>
-				<BusyIndicator active={this.loading} class="ui5-combobox-busy"/>
+				{this.loading &&
+					<BusyIndicator active={true} class="ui5-combobox-busy"/>
+				}
 
-				{this._isPhone &&
+				{!this.loading && this._isPhone &&
 				<>
 					<div slot="header" class="ui5-responsive-popover-header">
 						<div class="row">
@@ -79,7 +81,7 @@ export default function ComboBoxPopoverTemplate(this: ComboBox) {
 				</div>
 				}
 
-				{!!this._filteredItems.length &&
+				{!this.loading && !!this._filteredItems.length &&
 				<List
 					class="ui5-combobox-items-list"
 					separators="None"
diff --git a/packages/main/src/MultiComboBox.ts b/packages/main/src/MultiComboBox.ts
index 9a1ff3a4f9d8..4780dede4e5d 100644
--- a/packages/main/src/MultiComboBox.ts
+++ b/packages/main/src/MultiComboBox.ts
@@ -369,6 +369,14 @@ class MultiComboBox extends UI5Element implements IFormInputElement {
 	@property({ type: Boolean })
 	required = false;
 
+	/**
+	 * Indicates whether a loading indicator should be shown in the picker.
+	 * @default false
+	 * @public
+	 */
+	@property({ type: Boolean })
+	loading = false;
+
 	/**
 	 * Defines the filter type of the component.
 	 * @default "StartsWithPerTerm"
@@ -1868,8 +1876,8 @@ class MultiComboBox extends UI5Element implements IFormInputElement {
 	}
 
 	storeResponsivePopoverWidth() {
-		if (this.open && !this._listWidth) {
-			this._listWidth = this.list!.offsetWidth;
+		if (this.open && !this._listWidth && this.list) {
+			this._listWidth = this.list.offsetWidth;
 		}
 	}
 
diff --git a/packages/main/src/MultiComboBoxPopoverTemplate.tsx b/packages/main/src/MultiComboBoxPopoverTemplate.tsx
index af570b19acf2..6cf58720ca6b 100644
--- a/packages/main/src/MultiComboBoxPopoverTemplate.tsx
+++ b/packages/main/src/MultiComboBoxPopoverTemplate.tsx
@@ -10,6 +10,7 @@ import List from "./List.js";
 import PopoverHorizontalAlign from "./types/PopoverHorizontalAlign.js";
 import Popover from "./Popover.js";
 import CheckBox from "./CheckBox.js";
+import BusyIndicator from "./BusyIndicator.js";
 
 export default function MultiComboBoxPopoverTemplate(this: MultiComboBox) {
 	return (<>
@@ -31,7 +32,11 @@ export default function MultiComboBoxPopoverTemplate(this: MultiComboBox) {
 			open={this.open}
 			opener={this}
 		>
-			{this._isPhone && <>
+			{this.loading &&
+				<BusyIndicator active={true} class="ui5-multi-combobox-busy"/>
+			}
+
+			{!this.loading && this._isPhone && <>
 				<div slot="header" class="ui5-responsive-popover-header" style={this.styles.popoverHeader}>
 					<div class="row">
 						<span>{this._headerTitleText}</span>
@@ -70,7 +75,7 @@ export default function MultiComboBoxPopoverTemplate(this: MultiComboBox) {
 				{selectAllWrapper.call(this)}
 			</>}
 
-			{!this._isPhone && <>
+			{!this.loading && !this._isPhone && <>
 				{this.hasValueStateMessage &&
 					<div slot="header" onKeyDown={this._onListHeaderKeydown} class={this.classes.responsivePopoverHeaderValueState} style={this.styles.popoverValueStateMessage}>
 						<Icon class="ui5-input-value-state-message-icon" name={this._valueStateMessageIcon}></Icon>
@@ -81,11 +86,11 @@ export default function MultiComboBoxPopoverTemplate(this: MultiComboBox) {
 				{selectAllWrapper.call(this)}
 			</>}
 
-			{this.filterSelected ?
+			{!this.loading && this.filterSelected ?
 				<List separators="None" selectionMode="Multiple" class="ui5-multi-combobox-all-items-list" accessibleRole="ListBox">
 					{this.selectedItems.map(item => <slot name={item._individualSlot}></slot>)}
 				</List>
-				:
+				: !this.loading &&
 				<List separators="None" selectionMode="Multiple" class="ui5-multi-combobox-all-items-list" accessibleRole="ListBox" onKeyDown={this._onItemKeydown}>
 					{this._filteredItems.map(item => <slot name={item._individualSlot}></slot>)}
 				</List>
diff --git a/packages/main/src/themes/MultiComboBoxPopover.css b/packages/main/src/themes/MultiComboBoxPopover.css
index cea6ed902150..21115cc5c4a9 100644
--- a/packages/main/src/themes/MultiComboBoxPopover.css
+++ b/packages/main/src/themes/MultiComboBoxPopover.css
@@ -37,6 +37,23 @@
 	max-width: inherit;
 }
 
+.ui5-multi-combobox-busy {
+	position: absolute;
+	left: 50%;
+	top: 50%;
+	transform: translate(-50%,-50%);
+	z-index: 42;
+	display: flex;
+	justify-content: center;
+	align-items: center;
+	pointer-events: all;
+	width: 100%;
+}
+
+.ui5-multi-combobox-busy:not([active]) {
+	display: none;
+}
+
 [ui5-responsive-popover] [ui5-input] {
 	width: 100%;
 }
diff --git a/packages/main/test/pages/ComboBox.html b/packages/main/test/pages/ComboBox.html
index abf48ebbf21c..27cf28276793 100644
--- a/packages/main/test/pages/ComboBox.html
+++ b/packages/main/test/pages/ComboBox.html
@@ -192,6 +192,20 @@
 		SelectionChange call count: <span id="selection-change-count">0</span><br>
 	</div>
 
+	<div class="demo-section">
+		<span>Toggle Loading State</span>
+
+		<br />
+		<br />
+
+		<ui5-combobox id="toggle-loading-cb" class="combobox2auto">
+			<ui5-cb-item text="Item 1"></ui5-cb-item>
+			<ui5-cb-item text="Item 2"></ui5-cb-item>
+			<ui5-cb-item text="Item 3"></ui5-cb-item>
+		</ui5-combobox>
+		<ui5-button id="toggle-loading-btn">Toggle Loading</ui5-button>
+	</div>
+
 	<div class="demo-section">
 		<span>Lazy Loading - example does not work on IE11</span>
 
@@ -604,8 +618,13 @@ <h3>ComboBox Composition</h3>
 		document.getElementById("combo-focus").addEventListener("click", function () {
 			document.getElementById("combo").focus();
 		});
+
+		document.getElementById("toggle-loading-btn").addEventListener("click", function () {
+			const combo = document.getElementById("toggle-loading-cb");
+			combo.loading = !combo.loading;
+		});
 	</script>
 
 </body>
 
-</html>
\ No newline at end of file
+</html>
diff --git a/packages/main/test/pages/MultiComboBox.html b/packages/main/test/pages/MultiComboBox.html
index 20ddd9f28daa..082c29af7a2a 100644
--- a/packages/main/test/pages/MultiComboBox.html
+++ b/packages/main/test/pages/MultiComboBox.html
@@ -574,6 +574,21 @@ <h3>MultiComboBox in Compact</h3>
 		</ui5-multi-combobox>
 	</div>
 
+	<div class="demo-section">
+		<ui5-label>Toggle Loading State:</ui5-label>
+		<br />
+		<br />
+
+		<ui5-multi-combobox id="toggle-loading-mcb">
+			<ui5-mcb-item text="Item 1"></ui5-mcb-item>
+			<ui5-mcb-item text="Item 2"></ui5-mcb-item>
+			<ui5-mcb-item text="Item 3"></ui5-mcb-item>
+		</ui5-multi-combobox>
+		<br /><br />
+
+		<ui5-button id="toggle-loading-btn">Toggle Loading</ui5-button>
+	</div>
+
 	<div class="demo-section">
 		<span>Placeholder test</span>
 
@@ -816,8 +831,13 @@ <h3>MultiComboBox in Compact</h3>
 			e.preventDefault();
 			document.getElementById("mcb-form-submit").textContent = ++submitCounter;
 		});
+
+		document.getElementById("toggle-loading-btn").addEventListener("click", function () {
+			const mcb = document.getElementById("toggle-loading-mcb");
+			mcb.loading = !mcb.loading;
+		});
 	</script>
 
 </body>
 
-</html>
\ No newline at end of file
+</html>