diff --git a/monai/inferers/inferer.py b/monai/inferers/inferer.py
index ee94b1ebdb..f023db490e 100644
--- a/monai/inferers/inferer.py
+++ b/monai/inferers/inferer.py
@@ -11,6 +11,7 @@
 
 from __future__ import annotations
 
+import inspect
 import math
 import warnings
 from abc import ABC, abstractmethod
@@ -861,6 +862,96 @@ def __init__(self, scheduler: Scheduler) -> None:  # type: ignore[override]
 
         self.scheduler = scheduler
 
+    @staticmethod
+    def _scheduler_step_supports_kwarg(scheduler: Scheduler, kwarg: str) -> bool:
+        try:
+            return kwarg in inspect.signature(scheduler.step).parameters
+        except (TypeError, ValueError):
+            return False
+
+    @staticmethod
+    def _get_previous_sample_from_step_output(step_output: Any) -> torch.Tensor:
+        if isinstance(step_output, tuple):
+            return step_output[0]
+        if isinstance(step_output, Mapping):
+            return step_output["prev_sample"]
+        if hasattr(step_output, "prev_sample"):
+            return step_output.prev_sample
+        raise TypeError("Unsupported scheduler.step output. Expected a tuple or an object with `prev_sample`.")
+
+    @staticmethod
+    def _get_scheduler_name(scheduler: Scheduler) -> str:
+        if hasattr(scheduler, "_get_name"):
+            return scheduler._get_name()
+        return scheduler.__class__.__name__
+
+    @staticmethod
+    def _get_scheduler_config_value(scheduler: Scheduler, name: str, default: Any = None) -> Any:
+        config = getattr(scheduler, "config", None)
+        if isinstance(config, Mapping):
+            if name in config:
+                return config[name]
+        elif config is not None and hasattr(config, name):
+            return getattr(config, name)
+
+        if hasattr(scheduler, name):
+            return getattr(scheduler, name)
+        return default
+
+    @staticmethod
+    def _get_posterior_mean(
+        scheduler: Scheduler, timestep: int | torch.Tensor, x_0: torch.Tensor, x_t: torch.Tensor
+    ) -> torch.Tensor:
+        alpha_t = scheduler.alphas[timestep]
+        alpha_prod_t = scheduler.alphas_cumprod[timestep]
+        alpha_prod_t_prev = scheduler.alphas_cumprod[timestep - 1] if timestep > 0 else scheduler.one
+
+        x_0_coefficient = alpha_prod_t_prev.sqrt() * scheduler.betas[timestep] / (1 - alpha_prod_t)
+        x_t_coefficient = alpha_t.sqrt() * (1 - alpha_prod_t_prev) / (1 - alpha_prod_t)
+
+        return x_0_coefficient * x_0 + x_t_coefficient * x_t
+
+    def _get_posterior_variance(
+        self, scheduler: Scheduler, timestep: int | torch.Tensor, predicted_variance: torch.Tensor | None = None
+    ) -> torch.Tensor:
+        alpha_prod_t = scheduler.alphas_cumprod[timestep]
+        alpha_prod_t_prev = scheduler.alphas_cumprod[timestep - 1] if timestep > 0 else scheduler.one
+        variance = (1 - alpha_prod_t_prev) / (1 - alpha_prod_t) * scheduler.betas[timestep]
+        variance_type = self._get_scheduler_config_value(scheduler, "variance_type")
+
+        if variance_type == "fixed_small":
+            variance = torch.clamp(variance, min=1e-20)
+        elif variance_type == "fixed_large":
+            variance = scheduler.betas[timestep]
+        elif variance_type == "learned" and predicted_variance is not None:
+            return predicted_variance
+        elif variance_type == "learned_range" and predicted_variance is not None:
+            min_log = variance
+            max_log = scheduler.betas[timestep]
+            frac = (predicted_variance + 1) / 2
+            variance = frac * max_log + (1 - frac) * min_log
+
+        return variance
+
+    def _scheduler_step(
+        self,
+        scheduler: Scheduler,
+        model_output: torch.Tensor,
+        timestep: int | torch.Tensor,
+        sample: torch.Tensor,
+        next_timestep: int | torch.Tensor | None = None,
+    ) -> torch.Tensor:
+        step_kwargs = {}
+        if self._scheduler_step_supports_kwarg(scheduler, "return_dict"):
+            step_kwargs["return_dict"] = False
+
+        if isinstance(scheduler, RFlowScheduler):
+            step_output = scheduler.step(model_output, timestep, sample, next_timestep, **step_kwargs)  # type: ignore
+        else:
+            step_output = scheduler.step(model_output, timestep, sample, **step_kwargs)  # type: ignore
+
+        return self._get_previous_sample_from_step_output(step_output)
+
     def __call__(  # type: ignore[override]
         self,
         inputs: torch.Tensor,
@@ -940,7 +1031,12 @@ def sample(
             scheduler = self.scheduler
         image = input_noise
 
-        all_next_timesteps = torch.cat((scheduler.timesteps[1:], torch.tensor([0], dtype=scheduler.timesteps.dtype)))
+        all_next_timesteps = torch.cat(
+            (
+                scheduler.timesteps[1:],
+                torch.tensor([0], dtype=scheduler.timesteps.dtype, device=scheduler.timesteps.device),
+            )
+        )
         if verbose and has_tqdm:
             progress_bar = tqdm(
                 zip(scheduler.timesteps, all_next_timesteps),
@@ -984,10 +1080,9 @@ def sample(
                 model_output = model_output_uncond + cfg * (model_output_cond - model_output_uncond)
 
             # 2. compute previous image: x_t -> x_t-1
-            if not isinstance(scheduler, RFlowScheduler):
-                image, _ = scheduler.step(model_output, t, image)  # type: ignore
-            else:
-                image, _ = scheduler.step(model_output, t, image, next_t)  # type: ignore
+            image = self._scheduler_step(
+                scheduler=scheduler, model_output=model_output, timestep=t, sample=image, next_timestep=next_t
+            )
             if save_intermediates and t % intermediate_steps == 0:
                 intermediates.append(image)
 
@@ -1028,10 +1123,10 @@ def get_likelihood(
 
         if not scheduler:
             scheduler = self.scheduler
-        if scheduler._get_name() != "DDPMScheduler":
+        scheduler_name = self._get_scheduler_name(scheduler)
+        if scheduler_name != "DDPMScheduler":
             raise NotImplementedError(
-                f"Likelihood computation is only compatible with DDPMScheduler,"
-                f" you are using {scheduler._get_name()}"
+                f"Likelihood computation is only compatible with DDPMScheduler," f" you are using {scheduler_name}"
             )
         if mode not in ["crossattn", "concat"]:
             raise NotImplementedError(f"{mode} condition is not supported")
@@ -1046,7 +1141,7 @@ def get_likelihood(
         total_kl = torch.zeros(inputs.shape[0]).to(inputs.device)
         for t in progress_bar:
             timesteps = torch.full(inputs.shape[:1], t, device=inputs.device).long()
-            noisy_image = self.scheduler.add_noise(original_samples=inputs, noise=noise, timesteps=timesteps)
+            noisy_image = scheduler.add_noise(original_samples=inputs, noise=noise, timesteps=timesteps)
             diffusion_model = (
                 partial(diffusion_model, seg=seg)
                 if isinstance(diffusion_model, SPADEDiffusionModelUNet)
@@ -1059,7 +1154,8 @@ def get_likelihood(
                 model_output = diffusion_model(x=noisy_image, timesteps=timesteps, context=conditioning)
 
             # get the model's predicted mean,  and variance if it is predicted
-            if model_output.shape[1] == inputs.shape[1] * 2 and scheduler.variance_type in ["learned", "learned_range"]:
+            variance_type = self._get_scheduler_config_value(scheduler, "variance_type")
+            if model_output.shape[1] == inputs.shape[1] * 2 and variance_type in ["learned", "learned_range"]:
                 model_output, predicted_variance = torch.split(model_output, inputs.shape[1], dim=1)
             else:
                 predicted_variance = None
@@ -1072,15 +1168,17 @@ def get_likelihood(
 
             # 2. compute predicted original sample from predicted noise also called
             # "predicted x_0" of formula (15) from https://arxiv.org/pdf/2006.11239.pdf
-            if scheduler.prediction_type == "epsilon":
+            prediction_type = self._get_scheduler_config_value(scheduler, "prediction_type")
+            if prediction_type == "epsilon":
                 pred_original_sample = (noisy_image - beta_prod_t ** (0.5) * model_output) / alpha_prod_t ** (0.5)
-            elif scheduler.prediction_type == "sample":
+            elif prediction_type == "sample":
                 pred_original_sample = model_output
-            elif scheduler.prediction_type == "v_prediction":
+            elif prediction_type == "v_prediction":
                 pred_original_sample = (alpha_prod_t**0.5) * noisy_image - (beta_prod_t**0.5) * model_output
             # 3. Clip "predicted x_0"
-            if scheduler.clip_sample:
-                pred_original_sample = torch.clamp(pred_original_sample, -1, 1)
+            if self._get_scheduler_config_value(scheduler, "clip_sample"):
+                clip_sample_range = self._get_scheduler_config_value(scheduler, "clip_sample_range", 1.0)
+                pred_original_sample = torch.clamp(pred_original_sample, -clip_sample_range, clip_sample_range)
 
             # 4. Compute coefficients for pred_original_sample x_0 and current sample x_t
             # See formula (7) from https://arxiv.org/pdf/2006.11239.pdf
@@ -1092,11 +1190,15 @@ def get_likelihood(
             predicted_mean = pred_original_sample_coeff * pred_original_sample + current_sample_coeff * noisy_image
 
             # get the posterior mean and variance
-            posterior_mean = scheduler._get_mean(timestep=t, x_0=inputs, x_t=noisy_image)  # type: ignore[operator]
-            posterior_variance = scheduler._get_variance(timestep=t, predicted_variance=predicted_variance)  # type: ignore[operator]
+            posterior_mean = self._get_posterior_mean(scheduler=scheduler, timestep=t, x_0=inputs, x_t=noisy_image)
+            posterior_variance = self._get_posterior_variance(
+                scheduler=scheduler, timestep=t, predicted_variance=predicted_variance
+            )
 
             log_posterior_variance = torch.log(posterior_variance)
-            log_predicted_variance = torch.log(predicted_variance) if predicted_variance else log_posterior_variance
+            log_predicted_variance = (
+                torch.log(predicted_variance) if predicted_variance is not None else log_posterior_variance
+            )
 
             if t == 0:
                 # compute -log p(x_0|x_1)
@@ -1509,7 +1611,12 @@ def sample(  # type: ignore[override]
             scheduler = self.scheduler
         image = input_noise
 
-        all_next_timesteps = torch.cat((scheduler.timesteps[1:], torch.tensor([0], dtype=scheduler.timesteps.dtype)))
+        all_next_timesteps = torch.cat(
+            (
+                scheduler.timesteps[1:],
+                torch.tensor([0], dtype=scheduler.timesteps.dtype, device=scheduler.timesteps.device),
+            )
+        )
         if verbose and has_tqdm:
             progress_bar = tqdm(
                 zip(scheduler.timesteps, all_next_timesteps),
@@ -1583,10 +1690,9 @@ def sample(  # type: ignore[override]
                 model_output = model_output_uncond + cfg * (model_output_cond - model_output_uncond)
 
             # 3. compute previous image: x_t -> x_t-1
-            if not isinstance(scheduler, RFlowScheduler):
-                image, _ = scheduler.step(model_output, t, image)  # type: ignore
-            else:
-                image, _ = scheduler.step(model_output, t, image, next_t)  # type: ignore
+            image = self._scheduler_step(
+                scheduler=scheduler, model_output=model_output, timestep=t, sample=image, next_timestep=next_t
+            )
 
             if save_intermediates and t % intermediate_steps == 0:
                 intermediates.append(image)
@@ -1631,10 +1737,10 @@ def get_likelihood(  # type: ignore[override]
 
         if not scheduler:
             scheduler = self.scheduler
-        if scheduler._get_name() != "DDPMScheduler":
+        scheduler_name = self._get_scheduler_name(scheduler)
+        if scheduler_name != "DDPMScheduler":
             raise NotImplementedError(
-                f"Likelihood computation is only compatible with DDPMScheduler,"
-                f" you are using {scheduler._get_name()}"
+                f"Likelihood computation is only compatible with DDPMScheduler," f" you are using {scheduler_name}"
             )
         if mode not in ["crossattn", "concat"]:
             raise NotImplementedError(f"{mode} condition is not supported")
@@ -1647,7 +1753,7 @@ def get_likelihood(  # type: ignore[override]
         total_kl = torch.zeros(inputs.shape[0]).to(inputs.device)
         for t in progress_bar:
             timesteps = torch.full(inputs.shape[:1], t, device=inputs.device).long()
-            noisy_image = self.scheduler.add_noise(original_samples=inputs, noise=noise, timesteps=timesteps)
+            noisy_image = scheduler.add_noise(original_samples=inputs, noise=noise, timesteps=timesteps)
 
             diffuse = diffusion_model
             if isinstance(diffusion_model, SPADEDiffusionModelUNet):
@@ -1680,7 +1786,8 @@ def get_likelihood(  # type: ignore[override]
                     mid_block_additional_residual=mid_block_res_sample,
                 )
             # get the model's predicted mean,  and variance if it is predicted
-            if model_output.shape[1] == inputs.shape[1] * 2 and scheduler.variance_type in ["learned", "learned_range"]:
+            variance_type = self._get_scheduler_config_value(scheduler, "variance_type")
+            if model_output.shape[1] == inputs.shape[1] * 2 and variance_type in ["learned", "learned_range"]:
                 model_output, predicted_variance = torch.split(model_output, inputs.shape[1], dim=1)
             else:
                 predicted_variance = None
@@ -1693,15 +1800,17 @@ def get_likelihood(  # type: ignore[override]
 
             # 2. compute predicted original sample from predicted noise also called
             # "predicted x_0" of formula (15) from https://arxiv.org/pdf/2006.11239.pdf
-            if scheduler.prediction_type == "epsilon":
+            prediction_type = self._get_scheduler_config_value(scheduler, "prediction_type")
+            if prediction_type == "epsilon":
                 pred_original_sample = (noisy_image - beta_prod_t ** (0.5) * model_output) / alpha_prod_t ** (0.5)
-            elif scheduler.prediction_type == "sample":
+            elif prediction_type == "sample":
                 pred_original_sample = model_output
-            elif scheduler.prediction_type == "v_prediction":
+            elif prediction_type == "v_prediction":
                 pred_original_sample = (alpha_prod_t**0.5) * noisy_image - (beta_prod_t**0.5) * model_output
             # 3. Clip "predicted x_0"
-            if scheduler.clip_sample:
-                pred_original_sample = torch.clamp(pred_original_sample, -1, 1)
+            if self._get_scheduler_config_value(scheduler, "clip_sample"):
+                clip_sample_range = self._get_scheduler_config_value(scheduler, "clip_sample_range", 1.0)
+                pred_original_sample = torch.clamp(pred_original_sample, -clip_sample_range, clip_sample_range)
 
             # 4. Compute coefficients for pred_original_sample x_0 and current sample x_t
             # See formula (7) from https://arxiv.org/pdf/2006.11239.pdf
@@ -1713,11 +1822,15 @@ def get_likelihood(  # type: ignore[override]
             predicted_mean = pred_original_sample_coeff * pred_original_sample + current_sample_coeff * noisy_image
 
             # get the posterior mean and variance
-            posterior_mean = scheduler._get_mean(timestep=t, x_0=inputs, x_t=noisy_image)  # type: ignore[operator]
-            posterior_variance = scheduler._get_variance(timestep=t, predicted_variance=predicted_variance)  # type: ignore[operator]
+            posterior_mean = self._get_posterior_mean(scheduler=scheduler, timestep=t, x_0=inputs, x_t=noisy_image)
+            posterior_variance = self._get_posterior_variance(
+                scheduler=scheduler, timestep=t, predicted_variance=predicted_variance
+            )
 
             log_posterior_variance = torch.log(posterior_variance)
-            log_predicted_variance = torch.log(predicted_variance) if predicted_variance else log_posterior_variance
+            log_predicted_variance = (
+                torch.log(predicted_variance) if predicted_variance is not None else log_posterior_variance
+            )
 
             if t == 0:
                 # compute -log p(x_0|x_1)
diff --git a/tests/inferers/test_diffusion_inferer.py b/tests/inferers/test_diffusion_inferer.py
index 81874ed3a8..9e1a3072dd 100644
--- a/tests/inferers/test_diffusion_inferer.py
+++ b/tests/inferers/test_diffusion_inferer.py
@@ -24,6 +24,7 @@
 
 _, has_scipy = optional_import("scipy")
 _, has_einops = optional_import("einops")
+DiffusersDDPMScheduler, has_diffusers = optional_import("diffusers", name="DDPMScheduler")
 
 TEST_CASES = [
     [
@@ -126,6 +127,63 @@ def test_ddpm_sampler(self, model_params, input_shape):
         )
         self.assertEqual(len(intermediates), 10)
 
+    @skipUnless(has_einops and has_diffusers, "Requires einops and diffusers")
+    def test_diffusers_ddpm_call(self):
+        device = "cuda:0" if torch.cuda.is_available() else "cpu"
+        model = DiffusionModelUNet(
+            spatial_dims=2,
+            in_channels=1,
+            out_channels=1,
+            channels=[32, 64],
+            attention_levels=[False, True],
+            num_res_blocks=1,
+            num_head_channels=32,
+        )
+        model.to(device)
+        model.eval()
+        scheduler = DiffusersDDPMScheduler(num_train_timesteps=1000, beta_schedule="linear", prediction_type="epsilon")
+        scheduler.set_timesteps(num_inference_steps=50)
+        inferer = DiffusionInferer(scheduler=scheduler)
+
+        batch_size = 2
+        image_size = 32
+        inputs = torch.randn(batch_size, 1, image_size, image_size).to(device)
+        noise = torch.randn_like(inputs)
+        timesteps = torch.randint(0, scheduler.config.num_train_timesteps, (batch_size,)).long().to(device)
+        with torch.no_grad():
+            prediction = inferer(inputs=inputs, diffusion_model=model, noise=noise, timesteps=timesteps)
+
+        self.assertEqual(prediction.shape, inputs.shape)
+        scheduler.set_timesteps(num_inference_steps=2)
+        sample = inferer.sample(input_noise=noise, diffusion_model=model, scheduler=scheduler, verbose=False)
+        self.assertEqual(sample.shape, inputs.shape)
+
+    @skipUnless(has_einops and has_diffusers, "Requires einops and diffusers")
+    def test_diffusers_ddpm_get_likelihood(self):
+        device = "cuda:0" if torch.cuda.is_available() else "cpu"
+        model = DiffusionModelUNet(
+            spatial_dims=2,
+            in_channels=1,
+            out_channels=1,
+            channels=[8],
+            norm_num_groups=8,
+            attention_levels=[True],
+            num_res_blocks=1,
+            num_head_channels=8,
+        )
+        model.to(device)
+        model.eval()
+        inputs = torch.randn(2, 1, 8, 8).to(device)
+        scheduler = DiffusersDDPMScheduler(num_train_timesteps=10, beta_schedule="linear", prediction_type="epsilon")
+        inferer = DiffusionInferer(scheduler=scheduler)
+        scheduler.set_timesteps(num_inference_steps=10)
+        likelihood, intermediates = inferer.get_likelihood(
+            inputs=inputs, diffusion_model=model, scheduler=scheduler, save_intermediates=True
+        )
+        self.assertEqual(len(intermediates), 10)
+        self.assertEqual(intermediates[0].shape, inputs.shape)
+        self.assertEqual(likelihood.shape[0], inputs.shape[0])
+
     @parameterized.expand(TEST_CASES)
     @skipUnless(has_einops, "Requires einops")
     def test_ddim_sampler(self, model_params, input_shape):
diff --git a/tests/inferers/test_latent_diffusion_inferer.py b/tests/inferers/test_latent_diffusion_inferer.py
index ab80363cde..23dd594d8e 100644
--- a/tests/inferers/test_latent_diffusion_inferer.py
+++ b/tests/inferers/test_latent_diffusion_inferer.py
@@ -23,6 +23,7 @@
 from monai.utils import optional_import
 
 _, has_einops = optional_import("einops")
+DiffusersDDPMScheduler, has_diffusers = optional_import("diffusers", name="DDPMScheduler")
 TEST_CASES = [
     [
         "AutoencoderKL",
@@ -414,6 +415,46 @@ def test_sample_shape(
                 )
             self.assertEqual(sample.shape, input_shape)
 
+    @skipUnless(has_einops and has_diffusers, "Requires einops and diffusers")
+    def test_diffusers_ddpm_sample_shape(self):
+        device = "cuda:0" if torch.cuda.is_available() else "cpu"
+        stage_1 = AutoencoderKL(
+            spatial_dims=2,
+            in_channels=1,
+            out_channels=1,
+            channels=(4, 4),
+            latent_channels=3,
+            attention_levels=[False, False],
+            num_res_blocks=1,
+            with_encoder_nonlocal_attn=False,
+            with_decoder_nonlocal_attn=False,
+            norm_num_groups=4,
+        )
+        stage_2 = DiffusionModelUNet(
+            spatial_dims=2,
+            in_channels=3,
+            out_channels=3,
+            channels=[4, 4],
+            norm_num_groups=4,
+            attention_levels=[False, False],
+            num_res_blocks=1,
+            num_head_channels=4,
+        )
+        stage_1.to(device)
+        stage_2.to(device)
+        stage_1.eval()
+        stage_2.eval()
+
+        noise = torch.randn(1, 3, 4, 4).to(device)
+        scheduler = DiffusersDDPMScheduler(num_train_timesteps=10, beta_schedule="linear", prediction_type="epsilon")
+        inferer = LatentDiffusionInferer(scheduler=scheduler, scale_factor=1.0)
+        scheduler.set_timesteps(num_inference_steps=10)
+
+        sample = inferer.sample(
+            input_noise=noise, autoencoder_model=stage_1, diffusion_model=stage_2, scheduler=scheduler
+        )
+        self.assertEqual(sample.shape, (1, 1, 8, 8))
+
     @parameterized.expand(TEST_CASES)
     @skipUnless(has_einops, "Requires einops")
     def test_sample_shape_with_cfg(