diff --git a/guides/UK-Core-Implementation-Guide-STU3-Sequence/Home/Terminology/ValueSets/ValueSet-UKCore-AllergyManifestation.page.md b/guides/UK-Core-Implementation-Guide-STU3-Sequence/Home/Terminology/ValueSets/ValueSet-UKCore-AllergyManifestation.page.md
deleted file mode 100644
index 0f58c954..00000000
--- a/guides/UK-Core-Implementation-Guide-STU3-Sequence/Home/Terminology/ValueSets/ValueSet-UKCore-AllergyManifestation.page.md
+++ /dev/null
@@ -1,6 +0,0 @@
----
-subject: https://fhir.hl7.org.uk/ValueSet/UKCore-AllergyManifestation
----
-## UK Core Allergy Manifestation
-
-{{page:ValueSetTemplate}}
\ No newline at end of file
diff --git a/guides/UK-Core-Implementation-Guide-STU3-Sequence/Home/Terminology/ValueSets/toc.yaml b/guides/UK-Core-Implementation-Guide-STU3-Sequence/Home/Terminology/ValueSets/toc.yaml
index 11b7430e..ca936ad3 100644
--- a/guides/UK-Core-Implementation-Guide-STU3-Sequence/Home/Terminology/ValueSets/toc.yaml
+++ b/guides/UK-Core-Implementation-Guide-STU3-Sequence/Home/Terminology/ValueSets/toc.yaml
@@ -10,8 +10,6 @@
   filename: ValueSet-UKCore-AlcoholConsumption.page.md
 - name: ValueSet-UKCore-AllergyCode
   filename: ValueSet-UKCore-AllergyCode.page.md
-- name: ValueSet-UKCore-AllergyManifestation
-  filename: ValueSet-UKCore-AllergyManifestation.page.md
 - name: ValueSet-UKCore-AllergySubstance
   filename: ValueSet-UKCore-AllergySubstance.page.md
 - name: ValueSet-UKCore-AppointmentReasonCode
diff --git a/structuredefinitions/UKCore-AllergyIntolerance.xml b/structuredefinitions/UKCore-AllergyIntolerance.xml
index b82438bf..719166e5 100644
--- a/structuredefinitions/UKCore-AllergyIntolerance.xml
+++ b/structuredefinitions/UKCore-AllergyIntolerance.xml
@@ -83,13 +83,6 @@
         <valueSet value="https://fhir.hl7.org.uk/ValueSet/UKCore-AllergySubstance" />
       </binding>
     </element>
-    <element id="AllergyIntolerance.reaction.manifestation">
-      <path value="AllergyIntolerance.reaction.manifestation" />
-      <binding>
-        <strength value="preferred" />
-        <valueSet value="https://fhir.hl7.org.uk/ValueSet/UKCore-AllergyManifestation" />
-      </binding>
-    </element>
     <element id="AllergyIntolerance.reaction.severity">
       <path value="AllergyIntolerance.reaction.severity" />
       <short value="A clinical assessment of the severity of the reaction event as a whole." />
diff --git a/valuesets/ValueSet-UKCore-AllergyManifestation.xml b/valuesets/ValueSet-UKCore-AllergyManifestation.xml
index 5662236b..d2e04ae1 100644
--- a/valuesets/ValueSet-UKCore-AllergyManifestation.xml
+++ b/valuesets/ValueSet-UKCore-AllergyManifestation.xml
@@ -1,11 +1,11 @@
 <ValueSet xmlns="http://hl7.org/fhir">
   <id value="UKCore-AllergyManifestation" />
   <url value="https://fhir.hl7.org.uk/ValueSet/UKCore-AllergyManifestation" />
-  <version value="2.2.0" />
+  <version value="2.2.1" />
   <name value="UKCoreAllergyManifestation" />
   <title value="UK Core Allergy Manifestation" />
-  <status value="active" />
-  <date value="2022-08-26" />
+  <status value="retired" />
+  <date value="2026-05-20" />
   <publisher value="HL7 UK" />
   <contact>
     <name value="HL7 UK" />
@@ -16,7 +16,7 @@
       <rank value="1" />
     </telecom>
   </contact>
-  <description value="A set of codes that describe how a patient's allergy was manifested. Selected from the 'Health issues' simple reference set of the SNOMED CT UK coding system.&#13;&#13;
+  <description value="NOTICE: This ValueSet has been retired because Health issues simple reference set (1127581000000103) is retired. A set of codes that describe how a patient's allergy was manifested. Selected from the 'Health issues' simple reference set of the SNOMED CT UK coding system.&#13;&#13;
 Alternatively provides a code indicating a degrade of information about a clinical record entry.&#13;&#13;
 Where no SNOMED CT coded information is available, a specific code from the nullFlavor Code System can be used instead to indicate this." />
   <copyright value="Copyright &#169; 2021+ HL7 UK Licensed under the Apache License, Version 2.0 (the &quot;License&quot;); you may not use this file except in compliance with the License. You may obtain a copy of the License at  http://www.apache.org/licenses/LICENSE-2.0 Unless required by applicable law or agreed to in writing, software distributed under the License is distributed on an &quot;AS IS&quot; BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the License for the specific language governing permissions and limitations under the License. HL7&#174; FHIR&#174; standard Copyright &#169; 2011+ HL7 The HL7&#174; FHIR&#174; standard is used under the FHIR license. You may obtain a copy of the FHIR license at  https://www.hl7.org/fhir/license.html.&lt;br$gt;This value set includes content from SNOMED CT, which is copyright &#169; 2002+ International Health Terminology Standards Development Organisation (IHTSDO), and distributed by agreement between IHTSDO and HL7. Implementer use of SNOMED CT is not covered by this agreement." />