diff --git a/.github/workflows/python-tox-testing-dockstring-env.yml b/.github/workflows/python-tox-testing-dockstring-env.yml
index 5587cee9..062258b6 100644
--- a/.github/workflows/python-tox-testing-dockstring-env.yml
+++ b/.github/workflows/python-tox-testing-dockstring-env.yml
@@ -5,11 +5,21 @@ on:
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/core/chemistry/**'
+      - 'src/poli/core/util/chemistry/**'
+      - 'src/poli/objective_repository/dockstring/**'
+      - 'src/poli/tests/registry/chemistry/**'
   pull_request:
     types: [opened, synchronize, reopened, ready_for_review, closed]
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/core/chemistry/**'
+      - 'src/poli/core/util/chemistry/**'
+      - 'src/poli/objective_repository/dockstring/**'
+      - 'src/poli/tests/registry/chemistry/**'
   schedule:
     - cron: '0 0 * * 0'
 
diff --git a/.github/workflows/python-tox-testing-ehrlich-holo-env.yml b/.github/workflows/python-tox-testing-ehrlich-holo-env.yml
index f54e180b..71977179 100644
--- a/.github/workflows/python-tox-testing-ehrlich-holo-env.yml
+++ b/.github/workflows/python-tox-testing-ehrlich-holo-env.yml
@@ -5,11 +5,19 @@ on:
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/core/util/proteins/**'
+      - 'src/poli/objective_repository/ehrlich_holo/**'
+      - 'src/poli/tests/registry/toy_discrete_problems/test_ehrlich_holo.py'
   pull_request:
     types: [opened, synchronize, reopened, ready_for_review, closed]
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/core/util/proteins/**'
+      - 'src/poli/objective_repository/ehrlich_holo/**'
+      - 'src/poli/tests/registry/toy_discrete_problems/test_ehrlich_holo.py'
   schedule:
     - cron: '0 0 * * 0'
 
diff --git a/.github/workflows/python-tox-testing-lambo-env.yml b/.github/workflows/python-tox-testing-lambo-env.yml
index c521c28e..60d771b7 100644
--- a/.github/workflows/python-tox-testing-lambo-env.yml
+++ b/.github/workflows/python-tox-testing-lambo-env.yml
@@ -5,11 +5,17 @@ on:
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/objective_repository/foldx_rfp_lambo/**'
+      - 'src/poli/tests/registry/proteins/test_foldx_rfp_lambo.py'
   pull_request:
     types: [opened, synchronize, reopened, ready_for_review, closed]
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/objective_repository/foldx_rfp_lambo/**'
+      - 'src/poli/tests/registry/proteins/test_foldx_rfp_lambo.py'
   schedule:
     - cron: '0 0 * * 0'
 
diff --git a/.github/workflows/python-tox-testing-protein-env.yml b/.github/workflows/python-tox-testing-protein-env.yml
index 22639fda..606b3dbe 100644
--- a/.github/workflows/python-tox-testing-protein-env.yml
+++ b/.github/workflows/python-tox-testing-protein-env.yml
@@ -5,11 +5,23 @@ on:
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/objective_repository/foldx_*/**'
+      - 'src/poli/objective_repository/rfp_foldx_*/**'
+      - 'src/poli/core/proteins/**'
+      - 'src/poli/core/util/proteins/**'
+      - 'src/poli/tests/registry/proteins/**'
   pull_request:
     types: [opened, synchronize, reopened, ready_for_review, closed]
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/objective_repository/foldx_*/**'
+      - 'src/poli/objective_repository/rfp_foldx_*/**'
+      - 'src/poli/core/proteins/**'
+      - 'src/poli/core/util/proteins/**'
+      - 'src/poli/tests/registry/proteins/**'
   schedule:
     - cron: '0 0 * * 0'
 
diff --git a/.github/workflows/python-tox-testing-rasp-env.yml b/.github/workflows/python-tox-testing-rasp-env.yml
index 2be6fe18..0d8aba01 100644
--- a/.github/workflows/python-tox-testing-rasp-env.yml
+++ b/.github/workflows/python-tox-testing-rasp-env.yml
@@ -5,11 +5,23 @@ on:
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/objective_repository/rasp/**'
+      - 'src/poli/objective_repository/rfp_rasp/**'
+      - 'src/poli/core/proteins/**'
+      - 'src/poli/core/util/proteins/**'
+      - 'src/poli/tests/registry/proteins/test_rasp.py'
   pull_request:
     types: [opened, synchronize, reopened, ready_for_review, closed]
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/objective_repository/rasp/**'
+      - 'src/poli/objective_repository/rfp_rasp/**'
+      - 'src/poli/core/proteins/**'
+      - 'src/poli/core/util/proteins/**'
+      - 'src/poli/tests/registry/proteins/test_rasp.py'
   schedule:
     - cron: '0 0 * * 0'
 
diff --git a/.github/workflows/python-tox-testing-rmf-env.yml b/.github/workflows/python-tox-testing-rmf-env.yml
index 6d6380b6..e0a94b70 100644
--- a/.github/workflows/python-tox-testing-rmf-env.yml
+++ b/.github/workflows/python-tox-testing-rmf-env.yml
@@ -5,11 +5,19 @@ on:
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/objective_repository/rmf_landscape/**'
+      - 'src/poli/core/util/proteins/**'
+      - 'src/poli/tests/registry/proteins/test_rmf.py'
   pull_request:
     types: [opened, synchronize, reopened, ready_for_review, closed]
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/objective_repository/rmf_landscape/**'
+      - 'src/poli/core/util/proteins/**'
+      - 'src/poli/tests/registry/proteins/test_rmf.py'
   schedule:
     - cron: '0 0 * * 0'
 
diff --git a/.github/workflows/python-tox-testing-rosetta-env.yml b/.github/workflows/python-tox-testing-rosetta-env.yml
index a764b09d..57616b69 100644
--- a/.github/workflows/python-tox-testing-rosetta-env.yml
+++ b/.github/workflows/python-tox-testing-rosetta-env.yml
@@ -5,11 +5,19 @@ on:
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/objective_repository/rosetta_energy/**'
+      - 'src/poli/core/util/proteins/**'
+      - 'src/poli/tests/registry/proteins/test_rosetta.py'
   pull_request:
     types: [opened, synchronize, reopened, ready_for_review, closed]
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/objective_repository/rmf_landscape/**'
+      - 'src/poli/core/util/proteins/**'
+      - 'src/poli/tests/registry/proteins/test_rosetta.py'
   schedule:
     - cron: '0 0 * * 0'
 
diff --git a/.github/workflows/python-tox-testing-tdc-env.yml b/.github/workflows/python-tox-testing-tdc-env.yml
index 3b4aba98..cbcc98db 100644
--- a/.github/workflows/python-tox-testing-tdc-env.yml
+++ b/.github/workflows/python-tox-testing-tdc-env.yml
@@ -5,11 +5,19 @@ on:
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/core/chemistry/**'
+      - 'src/poli/core/util/chemistry/**'
+      - 'src/poli/tests/registry/chemistry/**'
   pull_request:
     types: [opened, synchronize, reopened, ready_for_review, closed]
     branches:
       - dev
       - master
+    paths:
+      - 'src/poli/core/chemistry/**'
+      - 'src/poli/core/util/chemistry/**'
+      - 'src/poli/tests/registry/chemistry/**'
   schedule:
     - cron: '0 0 * * 0'