diff --git a/src/Wrap/PyArray.jl b/src/Wrap/PyArray.jl
index 7b1dc8d3..dc11c085 100644
--- a/src/Wrap/PyArray.jl
+++ b/src/Wrap/PyArray.jl
@@ -531,6 +531,8 @@ end
 function PyArraySource_Buffer(x::Py)
     memview = pybuiltins.memoryview(x)
     buf = C.UnsafePtr(C.PyMemoryView_GET_BUFFER(memview))
+    buf.suboffsets[] == C_NULL ||
+        error("PyArray does not support buffers with non-trivial suboffsets (PIL-style indirect layout)")
     PyArraySource_Buffer(x, memview, buf)
 end
 
diff --git a/test/Wrap.jl b/test/Wrap.jl
index c42d45ab..5665003e 100644
--- a/test/Wrap.jl
+++ b/test/Wrap.jl
@@ -91,6 +91,17 @@
     end
 end
 
+@testitem "PyArray buffer with suboffsets is rejected" begin
+    tb = pyimport("_testbuffer")
+    nd = tb.ndarray(
+        pylist([1, 2, 3, 4, 5, 6]),
+        shape = pylist([2, 3]),
+        format = "i",
+        flags = tb.ND_PIL | tb.ND_WRITABLE,
+    )
+    @test_throws Exception PyArray(nd; array = false, buffer = true)
+end
+
 @testitem "PyDict" begin
     x = pydict(["foo" => 12])
     y = PyDict(x)