diff --git a/pyproject.toml b/pyproject.toml
index faaea88..0499cd4 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -30,7 +30,7 @@ dependencies = [
     "polars ~= 1.0",
     "biocommons.seqrepo",
     "pydantic >=2.0,<3.0",
-    "ga4gh.vrs >=2.1.4,<3.0",
+    "ga4gh.vrs >=2.2.0,<3.0",
     "wags-tails ~= 0.4.0",
     "bioutils",
 ]