diff --git a/sdk/ai/azure-ai-voicelive/README.md b/sdk/ai/azure-ai-voicelive/README.md
index e33bb7535f36..cf1b1a2d8bb4 100644
--- a/sdk/ai/azure-ai-voicelive/README.md
+++ b/sdk/ai/azure-ai-voicelive/README.md
@@ -33,6 +33,9 @@ python -m pip install azure-ai-voicelive
 python -m pip install "azure-ai-voicelive[aiohttp]"
 
 # For voice samples (includes audio processing)
+# First install PyAudio dependencies for your platform:
+#   Linux: sudo apt-get install -y portaudio19-dev libasound2-dev
+#   macOS: brew install portaudio
 python -m pip install azure-ai-voicelive[aiohttp] pyaudio python-dotenv
 ```
 
diff --git a/sdk/ai/azure-ai-voicelive/dev_requirements.txt b/sdk/ai/azure-ai-voicelive/dev_requirements.txt
index babde7a9e9a1..ffa5c1ebca5d 100644
--- a/sdk/ai/azure-ai-voicelive/dev_requirements.txt
+++ b/sdk/ai/azure-ai-voicelive/dev_requirements.txt
@@ -4,7 +4,7 @@ aiohttp
 python-dotenv
 isodate
 websockets
-pyaudio; platform_python_implementation == 'CPython' and python_version < '3.13'
+pyaudio; platform_python_implementation == 'CPython' and python_version < '3.13' and sys_platform == 'win32'
 azure.identity
 pytest-rerunfailures>=13.0
 pytest-asyncio
diff --git a/sdk/ai/azure-ai-voicelive/pyproject.toml b/sdk/ai/azure-ai-voicelive/pyproject.toml
index 5fdee2a8b6d1..3e2540ab6842 100644
--- a/sdk/ai/azure-ai-voicelive/pyproject.toml
+++ b/sdk/ai/azure-ai-voicelive/pyproject.toml
@@ -51,7 +51,7 @@ test = [
   "python-dotenv",
   "azure-identity",
   "soundfile",
-  "pyaudio; platform_python_implementation == 'CPython' and python_version < '3.13'",
+  "pyaudio; platform_python_implementation == 'CPython' and python_version < '3.13' and sys_platform == 'win32'",
 ]
 
 [project.urls]
diff --git a/sdk/ai/azure-ai-voicelive/samples/BASIC_VOICE_ASSISTANT.md b/sdk/ai/azure-ai-voicelive/samples/BASIC_VOICE_ASSISTANT.md
index 768f915a250d..ca7302cbd1a6 100644
--- a/sdk/ai/azure-ai-voicelive/samples/BASIC_VOICE_ASSISTANT.md
+++ b/sdk/ai/azure-ai-voicelive/samples/BASIC_VOICE_ASSISTANT.md
@@ -19,9 +19,29 @@ This sample demonstrates a complete voice assistant implementation using the Azu
 
 ## Installation
 
-```bash
-pip install azure-ai-voicelive pyaudio python-dotenv
-```
+1. **Install the SDK**:
+   ```bash
+   pip install azure-ai-voicelive python-dotenv
+   ```
+
+2. **Install PyAudio** (required for audio capture/playback):
+
+   PyAudio requires PortAudio to be installed on your system:
+
+   - **Linux (Ubuntu/Debian)**:
+     ```bash
+     sudo apt-get install -y portaudio19-dev libasound2-dev
+     pip install pyaudio
+     ```
+   - **macOS**:
+     ```bash
+     brew install portaudio
+     pip install pyaudio
+     ```
+   - **Windows**:
+     ```bash
+     pip install pyaudio
+     ```
 
 ## Configuration
 
diff --git a/sdk/ai/azure-ai-voicelive/samples/README.md b/sdk/ai/azure-ai-voicelive/samples/README.md
index 41529c87416f..bb113070478d 100644
--- a/sdk/ai/azure-ai-voicelive/samples/README.md
+++ b/sdk/ai/azure-ai-voicelive/samples/README.md
@@ -15,10 +15,29 @@ This directory contains sample applications demonstrating various capabilities o
 1. **Install dependencies**:
 
    ```bash
-   pip install azure-ai-voicelive[aiohttp] pyaudio python-dotenv
+   pip install azure-ai-voicelive[aiohttp] python-dotenv
    ```
 
-2. **Configure environment variables**:
+2. **Install PyAudio** (required for audio samples):
+
+   PyAudio requires PortAudio to be installed on your system:
+
+   - **Linux (Ubuntu/Debian)**:
+     ```bash
+     sudo apt-get install -y portaudio19-dev libasound2-dev
+     pip install pyaudio
+     ```
+   - **macOS**:
+     ```bash
+     brew install portaudio
+     pip install pyaudio
+     ```
+   - **Windows**:
+     ```bash
+     pip install pyaudio
+     ```
+
+3. **Configure environment variables**:
 
    Create a `.env` file at the root of the azure-ai-voicelive directory or in the samples directory with the following variables:
 
diff --git a/sdk/ai/azure-ai-voicelive/samples/async_function_calling_sample.py b/sdk/ai/azure-ai-voicelive/samples/async_function_calling_sample.py
index 4b804ef4e447..2d80f8bcb16b 100644
--- a/sdk/ai/azure-ai-voicelive/samples/async_function_calling_sample.py
+++ b/sdk/ai/azure-ai-voicelive/samples/async_function_calling_sample.py
@@ -45,7 +45,10 @@
 try:
     import pyaudio
 except ImportError:
-    print("This sample requires pyaudio. Install with: pip install pyaudio")
+    print("This sample requires pyaudio. Install with:")
+    print("  Linux: sudo apt-get install -y portaudio19-dev libasound2-dev && pip install pyaudio")
+    print("  macOS: brew install portaudio && pip install pyaudio")
+    print("  Windows: pip install pyaudio")
     sys.exit(1)
 
 # Environment variable loading
@@ -770,7 +773,12 @@ def signal_handler(sig, frame):
         print("❌ Missing required dependencies:")
         for dep in missing_deps:
             print(f"  - {dep}")
-        print("\nInstall with: pip install azure-ai-voicelive pyaudio python-dotenv")
+        print("\nInstall with:")
+        print("  pip install azure-ai-voicelive python-dotenv")
+        print("  For PyAudio:")
+        print("    Linux: sudo apt-get install -y portaudio19-dev libasound2-dev && pip install pyaudio")
+        print("    macOS: brew install portaudio && pip install pyaudio")
+        print("    Windows: pip install pyaudio")
         sys.exit(1)
 
     # Check audio system
diff --git a/sdk/ai/azure-ai-voicelive/samples/async_mcp_sample.py b/sdk/ai/azure-ai-voicelive/samples/async_mcp_sample.py
index a9f120caf6d6..dba44749167e 100644
--- a/sdk/ai/azure-ai-voicelive/samples/async_mcp_sample.py
+++ b/sdk/ai/azure-ai-voicelive/samples/async_mcp_sample.py
@@ -42,7 +42,10 @@
 try:
     import pyaudio
 except ImportError:
-    print("This sample requires pyaudio. Install with: pip install pyaudio")
+    print("This sample requires pyaudio. Install with:")
+    print("  Linux: sudo apt-get install -y portaudio19-dev libasound2-dev && pip install pyaudio")
+    print("  macOS: brew install portaudio && pip install pyaudio")
+    print("  Windows: pip install pyaudio")
     sys.exit(1)
 
 # Environment variable loading
@@ -707,7 +710,12 @@ def signal_handler(sig, frame):
         print("❌ Missing required dependencies:")
         for dep in missing_deps:
             print(f"  - {dep}")
-        print("\nInstall with: pip install azure-ai-voicelive pyaudio python-dotenv")
+        print("\nInstall with:")
+        print("  pip install azure-ai-voicelive python-dotenv")
+        print("  For PyAudio:")
+        print("    Linux: sudo apt-get install -y portaudio19-dev libasound2-dev && pip install pyaudio")
+        print("    macOS: brew install portaudio && pip install pyaudio")
+        print("    Windows: pip install pyaudio")
         sys.exit(1)
 
     # Check audio system
diff --git a/sdk/ai/azure-ai-voicelive/samples/supervisor_agent_sample.py b/sdk/ai/azure-ai-voicelive/samples/supervisor_agent_sample.py
index 9514cf835e63..2b43bcd1a85c 100644
--- a/sdk/ai/azure-ai-voicelive/samples/supervisor_agent_sample.py
+++ b/sdk/ai/azure-ai-voicelive/samples/supervisor_agent_sample.py
@@ -30,7 +30,10 @@
 try:
     import pyaudio
 except ImportError:
-    print("This sample requires pyaudio. Install with: pip install pyaudio")
+    print("This sample requires pyaudio. Install with:")
+    print("  Linux: sudo apt-get install -y portaudio19-dev libasound2-dev && pip install pyaudio")
+    print("  macOS: brew install portaudio && pip install pyaudio")
+    print("  Windows: pip install pyaudio")
     sys.exit(1)
 
 # Environment variable loading
@@ -599,7 +602,12 @@ def signal_handler(sig, frame):
         print("❌ Missing required dependencies:")
         for dep in missing_deps:
             print(f"  - {dep}")
-        print("\nInstall with: pip install azure-ai-voicelive pyaudio python-dotenv")
+        print("\nInstall with:")
+        print("  pip install azure-ai-voicelive python-dotenv")
+        print("  For PyAudio:")
+        print("    Linux: sudo apt-get install -y portaudio19-dev libasound2-dev && pip install pyaudio")
+        print("    macOS: brew install portaudio && pip install pyaudio")
+        print("    Windows: pip install pyaudio")
         sys.exit(1)
 
     # Check audio system